000151081 001__ 151081
000151081 005__ 20250221105703.0
000151081 0247_ $$2doi$$a10.1111/ijpo.13205
000151081 0248_ $$2sideral$$a142887
000151081 037__ $$aART-2025-142887
000151081 041__ $$aeng
000151081 100__ $$aBaxevanis, Georgios K.
000151081 245__ $$aInteraction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The <scp>HELENA</scp> study
000151081 260__ $$c2025
000151081 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151081 5203_ $$aBackground: Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity. Objectives: To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents. Methods: Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1–3 months and ≥4 months. Adjusting by socioeconomic status and lifestyle factors multiple linear regression models were used to assess (1) the main effect of breastfeeding duration and (2) its interaction effect with an obesity GRS, to predict different adiposity measures. Results: A significant negative association between ≥4 months of breastfeeding and waist circumference (WC) z-score was observed [β (95% confidence interval), p-value] = [β = −0.189 (−0.37, −0.00), p = 0.044]. Also, significant interaction effects were observed for 1–3 and ≥4 months of breastfeeding and obesity GRS regarding body mass index (BMI) z-score [β = 0.155 (0.06, 0.24), p = 0.001] and [β = 0.108 (0.01, 0.18), p = 0.020, respectively] and fat mass index (FMI) z-score [β = 0.134 (0.04, 0.22), p = 0.003] and [β = 0.100 (0.01, 0.18), p = 0.026, respectively]. Conclusions: Breastfeeding modulates the association between the obesity GRS and body composition in adolescents.
000151081 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOODCT-2005-007034$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00988
000151081 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151081 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151081 700__ $$0(orcid)0000-0002-2219-3646$$aIglesia, Iris
000151081 700__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortes, Miguel$$uUniversidad de Zaragoza
000151081 700__ $$aSabroso-Lasa, Sergio
000151081 700__ $$0(orcid)0000-0002-2135-900X$$aFlores-Barrantes, Paloma
000151081 700__ $$aGottrand, Frédéric
000151081 700__ $$aMeirhaeghe, Aline
000151081 700__ $$aKafatos, Anthony
000151081 700__ $$aWidhalm, Kurt
000151081 700__ $$aHockamp, Nele
000151081 700__ $$aMolnár, Dénes
000151081 700__ $$aMarcos, Ascensión
000151081 700__ $$aNova, Esther
000151081 700__ $$aGonzález-Gross, Marcela
000151081 700__ $$aGesteiro, Eva
000151081 700__ $$aGutiérrez, Ángel
000151081 700__ $$aManios, Yannis
000151081 700__ $$aAnastasiou, Costas A.
000151081 700__ $$0(orcid)0000-0002-7985-9912$$aRodríguez, Gerardo$$uUniversidad de Zaragoza
000151081 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000151081 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000151081 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000151081 773__ $$g20, 3 (2025), e13205[13 pp.]$$pPediatr. obes.$$tPediatric obesity$$x2047-6302
000151081 8564_ $$s1825989$$uhttps://zaguan.unizar.es/record/151081/files/texto_completo.pdf$$yVersión publicada
000151081 8564_ $$s2051159$$uhttps://zaguan.unizar.es/record/151081/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151081 909CO $$ooai:zaguan.unizar.es:151081$$particulos$$pdriver
000151081 951__ $$a2025-02-21-09:54:00
000151081 980__ $$aARTICLE