000151116 001__ 151116
000151116 005__ 20250227101503.0
000151116 0247_ $$2doi$$a10.1038/s41598-025-89734-2
000151116 0248_ $$2sideral$$a143024
000151116 037__ $$aART-2025-143024
000151116 041__ $$aeng
000151116 100__ $$aArias-Alvarez, Marta
000151116 245__ $$aEarly detection of retinal dysfunction in type 1 diabetes without retinopathy using multifocal electroretinography
000151116 260__ $$c2025
000151116 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151116 5203_ $$aDiabetic retinopathy (DR) significantly impacts vision and quality of life in diabetic patients. This study aimed to evaluate multifocal electroretinogram (mfERG) changes in long-term type 1 diabetes mellitus (T1DM) patients without clinical signs of DR to detect early functional retinal alterations. A prospective observational study was conducted involving 46 eyes from 23 T1DM patients and 46 eyes from 23 age-matched healthy controls. mfERG was assessed using the RETI-port/scan21 following ISCEV protocols. T1DM patients exhibited significantly decreased mfERG response amplitude density (RAD) in all the retinal rings except R2 (R1, p = 0.003; R3, p = 0.006, R4, p = 0.023 and R5, p = 0,027) and in the inferior quadrants Q2 and Q3 (p = 0.030 and p = 0.004, respectively) compared to controls. Minimal differences in implicit time (IT) were observed between both groups. Age correlated positively with different ITs, and HbA1c showed a significant negative correlation with various RADs. T1DM patients show early retinal dysfunction, as indicated by reduced RAD in mfERG, even without clinical signs of DR. These findings highlight the importance of early functional testing and metabolic control in preventing DR progression. RAD may serve as a subclinical marker of bipolar cell and photoreceptor damage in long-term T1DM patients prior to the onset of clinical DR.
000151116 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000151116 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151116 700__ $$aSopeña-Pinilla, Maria
000151116 700__ $$0(orcid)0000-0003-1234-9712$$aFernandez-Espinosa, Guisela$$uUniversidad de Zaragoza
000151116 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000151116 700__ $$aRodriguez-Mena, Diego$$uUniversidad de Zaragoza
000151116 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000151116 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151116 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000151116 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000151116 773__ $$g15 (2025), 6379 [13 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000151116 8564_ $$s2782818$$uhttps://zaguan.unizar.es/record/151116/files/texto_completo.pdf$$yVersión publicada
000151116 8564_ $$s2575202$$uhttps://zaguan.unizar.es/record/151116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151116 909CO $$ooai:zaguan.unizar.es:151116$$particulos$$pdriver
000151116 951__ $$a2025-02-27-09:25:25
000151116 980__ $$aARTICLE