Characterization of encapsulated porcine cardiosphere-derived cells embedded in 3D alginate matrices

Ziani, K. ; Espona-Noguera, A. ; Crisostomo, V. ; Casado, J.G. ; Sanchez-Margallo, F.M. ; Saenz-del-Burgo, L. ; Ciriza, J. (Universidad de Zaragoza) ; Pedraz, J.L.

Resumen: Myocardial infarction is caused by an interruption of coronary blood flow, leading to one of the main death causes worldwide. Current therapeutic approaches are palliative and not able to solve the loss of cardiac tissue. Cardiosphere derived cells (CDCs) reduce scarring, and increase viable myocardium, with safety and adequate biodistribution, but show a low rate engraftment and survival after implantation. In order to solve the low retention, we propose the encapsulation of CDCs within three-dimensional alginate-poly-L-lysine-alginate matrix as therapy for cardiac regeneration. In this work, we demonstrate the encapsulation of CDCs in alginate matrix, with no decrease in viability over a month, and showing the preservation of CDCs phenotype, differentiation potential, gene expression profile and growth factor release after encapsulation, moving a step forward to clinical translation of CDCs therapy in regeneration in heart failure.

Idioma: Inglés

DOI: 10.1016/j.ijpharm.2021.120454

Año: 2021

Publicado en: International Journal of Pharmaceutics 599 (2021), [11 pp.]
ISSN: 0378-5173

Factor impacto JCR: 6.51 (2021)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 40 / 279 = 0.143 (2021) - Q1 - T1

Factor impacto CITESCORE: 9.6 - Pharmacology, Toxicology and Pharmaceutics (Q1)

Factor impacto SCIMAGO: 1.0 - Pharmaceutical Science (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/78132/EU/Electronic Components and Systems for European Leadership Joint Undertaking/ECSEL JU-78132-Position-II-2017-IA

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)