000151124 001__ 151124
000151124 005__ 20251017144605.0
000151124 0247_ $$2doi$$a10.1016/j.ebiom.2021.103254
000151124 0248_ $$2sideral$$a124307
000151124 037__ $$aART-2021-124307
000151124 041__ $$aeng
000151124 100__ $$0(orcid)0000-0003-4155-749X$$aBroset, E.
000151124 245__ $$aBCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies
000151124 260__ $$c2021
000151124 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151124 5203_ $$aBackground: The Bacillus Calmette-Guérin (BCG), the only vaccine against tuberculosis (TB) currently in use, has shown beneficial effects against unrelated infections and to enhance immune responses to vaccines. However, there is little evidence regarding the influence of BCG vaccination on pertussis. Methods: Here, we studied the ability of BCG to improve the immune responses to diphtheria, tetanus, and acellular (DTaP) or whole-cell pertussis (DTwP) vaccination in a mouse model. We included MTBVAC, an experimental live-attenuated vaccine derived from Mycobacterium tuberculosis, in our studies to explore if it presents similar heterologous immunity as BCG. Furthermore, we explored the potential effect of routine BCG vaccination on pertussis incidence worldwide. Findings: We found that both BCG and MTBVAC when administered before DTaP, triggered Th1 immune responses against diphtheria, tetanus, and pertussis in mice. Immunization with DTaP alone failed to trigger a Th1 response, as measured by the production of IFN-¿. Humoral responses against DTaP antigens were also enhanced by previous immunization with BCG or MTBVAC. Furthermore, exploration of human epidemiological data showed that pertussis incidence was 10-fold lower in countries that use DTaP and BCG compared to countries that use only DTaP. Interpretation: BCG vaccination may have a beneficial impact on the protection against pertussis conferred by DTaP. Further randomized controlled trials are needed to properly define the impact of BCG on pertussis incidence in a controlled setting. This could be a major finding that would support changes in immunization policies.
000151124 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/EUR/EDCTP/RIA2016V-1637$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01478$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01569$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI07-0069$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-00540$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-01090$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097625-B-I00$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2012-052937$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2015-72190-EXP
000151124 540__ $$9info:eu-repo/semantics/openAccess$$aby-nd$$uhttps://creativecommons.org/licenses/by-nd/4.0/deed.es
000151124 590__ $$a11.205$$b2021
000151124 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b14 / 139 = 0.101$$c2021$$dQ1$$eT1
000151124 592__ $$a2.663$$b2021
000151124 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151124 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2021$$dQ1
000151124 594__ $$a15.0$$b2021
000151124 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151124 700__ $$aPardo-Seco, J.
000151124 700__ $$aKanno, A.I.
000151124 700__ $$aAguilo, N.
000151124 700__ $$aDacosta, A.I.
000151124 700__ $$aRivero-Calle, I.
000151124 700__ $$0(orcid)0000-0001-8841-6593$$aGonzalo-Asensio, J.$$uUniversidad de Zaragoza
000151124 700__ $$aLocht, C.
000151124 700__ $$aLeite, L.C.C.
000151124 700__ $$0(orcid)0000-0003-2993-5478$$aMartin, C.$$uUniversidad de Zaragoza
000151124 700__ $$aMartinón-Torres, F.
000151124 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000151124 773__ $$g65 (2021), 103254 [12 pp.]$$pEBioMedicine$$tEBioMedicine$$x2352-3964
000151124 8564_ $$s2076138$$uhttps://zaguan.unizar.es/record/151124/files/texto_completo.pdf$$yVersión publicada
000151124 8564_ $$s2308285$$uhttps://zaguan.unizar.es/record/151124/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151124 909CO $$ooai:zaguan.unizar.es:151124$$particulos$$pdriver
000151124 951__ $$a2025-10-17-14:15:14
000151124 980__ $$aARTICLE