Synthesis of new thiourea-metal complexes with promising anticancer properties

Canudo Barreras G. ; Ortego L. ; Izaga, A. ; Marzo Rubio I. (Universidad de Zaragoza) ; Pérez Herrera R. ; Gimeno M.C.

Resumen: In this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3, 5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is observed for gold complexes, a linear geometry with coordination only to the phosphorus atom or an equilibrium between the linear and three-coordinated species is present, whereas for silver complexes the coordination of the ligand as PˆS chelate is found. The thiourea ligands and their complexes were explored against different cancer cell lines (HeLa, A549, and Jurkat). The thiourea ligands do not exhibit relevant cytotoxicity in the tested cell lines and the coordination of a metal triggers excellent cytotoxic values in all cases. In general, data showed that gold complexes are more cytotoxic than the silver compounds with T1, in particular the complexes [AuT1(PPh3)]OTf, the bis(thiourea) [Au(T1)2 ]OTf and the gold-thiolate species [Au(SR)T1]. In contrast, with T2 better results are obtained with silver species [AgT1(PPh3)]OTf and the [Ag(T1)2 ]OTf. The role played by the ancillary ligand bound to the metal is important since it strongly affects the cytotoxic activity, being the bis(thiourea) complex the most active species. This study demonstrates that metal complexes derived from thiourea can be biologically active and these compounds are promising leads for further development as potential anticancer agents.

Idioma: Inglés

DOI: 10.3390/molecules26226891

Año: 2021

Publicado en: Molecules 26, 22 (2021), 6891 [16 pp.]
ISSN: 1420-3049

Factor impacto JCR: 4.927 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 114 / 297 = 0.384 (2021) - Q2 - T2
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 65 / 179 = 0.363 (2021) - Q2 - T2

Factor impacto CITESCORE: 5.9 - Pharmacology, Toxicology and Pharmaceutics (Q2) - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 0.705 - Analytical Chemistry (Q1) - Drug Discovery (Q1) - Pharmaceutical Science (Q1) - Molecular Medicine (Q1) - Organic Chemistry (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/AEI/FEDER/CTQ2017-88091-P
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)