000151146 001__ 151146
000151146 005__ 20251017144607.0
000151146 0247_ $$2doi$$a10.14309/ctg.0000000000000301
000151146 0248_ $$2sideral$$a124351
000151146 037__ $$aART-2021-124351
000151146 041__ $$aeng
000151146 100__ $$0(orcid)0000-0002-3545-2707$$aGargallo-Puyuelo, C.J.$$uUniversidad de Zaragoza
000151146 245__ $$aFamilial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer
000151146 260__ $$c2021
000151146 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151146 5203_ $$aINTRODUCTION: Epidemiological studies estimate that having a first-degree relative (FDR) with colorectal cancer (CRC) increases 2-fold to 3-fold the risk of developing the disease. Because FDRs of CRC patients are more likely to co-inherit CRC risk variants, we aimed to evaluate potential differences in genotype distribution of single nucleotide polymorphisms (SNPs) related to CRC risk between FDRs of patients with nonsyndromic CRC (cases) and individuals with no family history of CRC (controls). METHODS: We designed a case-control study comprising 750 cases and 750 Spanish Caucasian controls matched by sex, age, and histological findings after colonoscopy. Genomic DNA from all participants was genotyped for 88 SNPs associated with CRC risk using the MassArray (Sequenom) platform. RESULTS: Ten of the 88 SNPs analyzed revealed significant associations (P < 0.05) with a family history of CRC in our population. The most robust associations were found for the rs17094983G>A SNP in the long noncoding RNA LINC01500 (odds ratio = 0.72; 95% confidence interval: 0.58-0.88, log-additive model), and the rs11255841T>A SNP in the long noncoding RNA LINC00709 (odds ratio = 2.04; 95% confidence interval: 1.19-3.51, dominant model). Of interest, the observed associations were in the same direction than those reported for CRC risk. DISCUSSION: FDRs of CRC patients show significant differences in genotype distribution of SNPs related to CRC risk as compared to individuals with no family history of CRC. Genotyping of CRC risk variants in FDRs of CRC patients may help to identify subjects at risk that would benefit from stricter surveillance and CRC screening programs.
000151146 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PT17-0019
000151146 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000151146 590__ $$a4.396$$b2021
000151146 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b42 / 92 = 0.457$$c2021$$dQ2$$eT2
000151146 592__ $$a1.249$$b2021
000151146 593__ $$aGastroenterology$$c2021$$dQ1
000151146 594__ $$a5.2$$b2021
000151146 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151146 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Á.$$uUniversidad de Zaragoza
000151146 700__ $$aCarrera-Lasfuentes, P.
000151146 700__ $$0(orcid)0000-0003-2280-9372$$aFerrández, Á.$$uUniversidad de Zaragoza
000151146 700__ $$aQuintero, E.
000151146 700__ $$aCarrillo, M.
000151146 700__ $$aAlonso-Abreu, I.
000151146 700__ $$aGarcía-González, M.A.
000151146 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151146 773__ $$g12, 2 (2021), e00301 [7 pp.]$$pCli. transl. gastroenterol.$$tClinical and Translational Gastroenterology$$x2155-384X
000151146 8564_ $$s445421$$uhttps://zaguan.unizar.es/record/151146/files/texto_completo.pdf$$yVersión publicada
000151146 8564_ $$s2718790$$uhttps://zaguan.unizar.es/record/151146/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151146 909CO $$ooai:zaguan.unizar.es:151146$$particulos$$pdriver
000151146 951__ $$a2025-10-17-14:15:53
000151146 980__ $$aARTICLE