000151161 001__ 151161
000151161 005__ 20250227101504.0
000151161 0247_ $$2doi$$a10.3390/pharmaceutics13091473
000151161 0248_ $$2sideral$$a125804
000151161 037__ $$aART-2021-125804
000151161 041__ $$aeng
000151161 100__ $$aRaslan A.
000151161 245__ $$aModulation of conductivity of alginate hydrogels containing reduced graphene oxide through the addition of proteins
000151161 260__ $$c2021
000151161 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151161 5203_ $$aModifying hydrogels in order to enhance their conductivity is an exciting field with applications in cardio and neuro-regenerative medicine. Therefore, we have designed hybrid alginate hydrogels containing uncoated and protein-coated reduced graphene oxide (rGO). We specifically studied the adsorption of three different proteins, BSA, elastin, and collagen, and the outcomes when these protein-coated rGO nanocomposites are embedded within the hydrogels. Our results demon-strate that BSA, elastin, and collagen are adsorbed onto the rGO surface, through a non-spontaneous phenomenon that fits Langmuir and pseudo-second-order adsorption models. Protein-coated rGOs are able to preclude further adsorption of erythropoietin, but not insulin. Collagen showed better adsorption capacity than BSA and elastin due to its hydrophobic nature, although requiring more energy. Moreover, collagen-coated rGO hybrid alginate hydrogels showed an enhancement in conductivity, showing that it could be a promising conductive scaffold for regenerative medicine.
000151161 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151161 590__ $$a6.525$$b2021
000151161 591__ $$aPHARMACOLOGY & PHARMACY$$b39 / 279 = 0.14$$c2021$$dQ1$$eT1
000151161 592__ $$a0.922$$b2021
000151161 593__ $$aPharmaceutical Science$$c2021$$dQ1
000151161 594__ $$a6.0$$b2021
000151161 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151161 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza J.$$uUniversidad de Zaragoza
000151161 700__ $$aOchoa de Retana A.M.
000151161 700__ $$0(orcid)0000-0002-5793-2058$$aSanjuán M.L.
000151161 700__ $$aToprak M.S.
000151161 700__ $$aGálvez P.
000151161 700__ $$aSaenz-Del-burgo L.
000151161 700__ $$aPedraz J.L.
000151161 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000151161 773__ $$g13, 9 (2021), 1473 [18 pp.]$$pPharmaceutics$$tPharmaceutics$$x1999-4923
000151161 8564_ $$s2669835$$uhttps://zaguan.unizar.es/record/151161/files/texto_completo.pdf$$yVersión publicada
000151161 8564_ $$s2786070$$uhttps://zaguan.unizar.es/record/151161/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151161 909CO $$ooai:zaguan.unizar.es:151161$$particulos$$pdriver
000151161 951__ $$a2025-02-27-09:26:37
000151161 980__ $$aARTICLE