151161 20251017144609.0 doi 10.3390/pharmaceutics13091473 sideral 125804 ART-2021-125804 eng Raslan A. Modulation of conductivity of alginate hydrogels containing reduced graphene oxide through the addition of proteins 2021 Access copy available to the general public Unrestricted Modifying hydrogels in order to enhance their conductivity is an exciting field with applications in cardio and neuro-regenerative medicine. Therefore, we have designed hybrid alginate hydrogels containing uncoated and protein-coated reduced graphene oxide (rGO). We specifically studied the adsorption of three different proteins, BSA, elastin, and collagen, and the outcomes when these protein-coated rGO nanocomposites are embedded within the hydrogels. Our results demon-strate that BSA, elastin, and collagen are adsorbed onto the rGO surface, through a non-spontaneous phenomenon that fits Langmuir and pseudo-second-order adsorption models. Protein-coated rGOs are able to preclude further adsorption of erythropoietin, but not insulin. Collagen showed better adsorption capacity than BSA and elastin due to its hydrophobic nature, although requiring more energy. Moreover, collagen-coated rGO hybrid alginate hydrogels showed an enhancement in conductivity, showing that it could be a promising conductive scaffold for regenerative medicine. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.525 2021 PHARMACOLOGY & PHARMACY 39 / 279 = 0.14 2021 Q1 T1 0.922 2021 Pharmaceutical Science 2021 Q1 6.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ciriza J. Universidad de Zaragoza (orcid)0000-0002-8666-622X Ochoa de Retana A.M. Sanjuán M.L. (orcid)0000-0002-5793-2058 Toprak M.S. Gálvez P. Saenz-Del-burgo L. Pedraz J.L. 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 13, 9 (2021), 1473 [18 pp.] Pharmaceutics Pharmaceutics 1999-4923 2669835 http://zaguan.unizar.es/record/151161/files/texto_completo.pdf Versión publicada 2786070 http://zaguan.unizar.es/record/151161/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151161 articulos driver 2025-10-17-14:16:28 ARTICLE