000151168 001__ 151168
000151168 005__ 20251017144609.0
000151168 0247_ $$2doi$$a10.3390/molecules26196062
000151168 0248_ $$2sideral$$a125273
000151168 037__ $$aART-2021-125273
000151168 041__ $$aeng
000151168 100__ $$aSancineto, Luca
000151168 245__ $$al-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells
000151168 260__ $$c2021
000151168 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151168 5203_ $$aThe COVID-19 pandemic outbreak prompts an urgent need for efficient therapeutics, and repurposing of known drugs has been extensively used in an attempt to get to anti-SARS-CoV-2 agents in the shortest possible time. The glycoside rutin shows manifold pharmacological activities and, despite its use being limited by its poor solubility in water, it is the active principle of many pharmaceutical preparations. We herein report our in silico and experimental investigations of rutin as a SARS-CoV-2 Mpro inhibitor and of its water solubility improvement obtained by mixing it with l-arginine. Tests of the rutinl-arginine mixture in a cellular model of SARS-CoV-2 infection highlighted that the mixture still suffers from unfavorable pharmacokinetic properties, but nonetheless, the results of this study suggest that rutin might be a good starting point for hit optimization.
000151168 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-20R$$9info:eu-repo/grantAgreement/ES/DGA/E45-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/CPII13-00017$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BES-2017-080739$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P
000151168 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151168 590__ $$a4.927$$b2021
000151168 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b65 / 179 = 0.363$$c2021$$dQ2$$eT2
000151168 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b114 / 297 = 0.384$$c2021$$dQ2$$eT2
000151168 592__ $$a0.705$$b2021
000151168 593__ $$aAnalytical Chemistry$$c2021$$dQ1
000151168 593__ $$aDrug Discovery$$c2021$$dQ1
000151168 593__ $$aPharmaceutical Science$$c2021$$dQ1
000151168 593__ $$aMolecular Medicine$$c2021$$dQ1
000151168 593__ $$aOrganic Chemistry$$c2021$$dQ1
000151168 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151168 594__ $$a5.9$$b2021
000151168 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151168 700__ $$aOstacolo, Carmine
000151168 700__ $$0(orcid)0000-0003-1885-4365$$aOrtega-Alarcon, David$$uUniversidad de Zaragoza
000151168 700__ $$0(orcid)0000-0003-4726-7821$$aJimenez-Alesanco, Ana$$uUniversidad de Zaragoza
000151168 700__ $$0(orcid)0000-0003-1892-5063$$aCeballos-Laita, Laura
000151168 700__ $$0(orcid)0000-0002-1232-6310$$aVega, Sonia
000151168 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, Olga$$uUniversidad de Zaragoza
000151168 700__ $$0(orcid)0000-0001-5702-4538$$aVelazquez-Campoy, Adrian$$uUniversidad de Zaragoza
000151168 700__ $$aMoretti, Silvia
000151168 700__ $$aDabrowska, Agnieszka
000151168 700__ $$aBotwina, Pawel
000151168 700__ $$aSynowiec, Aleksandra
000151168 700__ $$aKula-Pacurar, Anna
000151168 700__ $$aPyrc, Krzysztof
000151168 700__ $$aIraci, Nunzio
000151168 700__ $$aSanti, Claudio
000151168 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000151168 773__ $$g26, 19 (2021), 6062 [14 pp.]$$pMolecules (Basel, Online)$$tMolecules$$x1420-3049
000151168 8564_ $$s4627242$$uhttps://zaguan.unizar.es/record/151168/files/texto_completo.pdf$$yVersión publicada
000151168 8564_ $$s2713952$$uhttps://zaguan.unizar.es/record/151168/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151168 909CO $$ooai:zaguan.unizar.es:151168$$particulos$$pdriver
000151168 951__ $$a2025-10-17-14:16:35
000151168 980__ $$aARTICLE