151168 20251017144609.0 doi 10.3390/molecules26196062 sideral 125273 ART-2021-125273 eng Sancineto, Luca l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells 2021 Access copy available to the general public Unrestricted The COVID-19 pandemic outbreak prompts an urgent need for efficient therapeutics, and repurposing of known drugs has been extensively used in an attempt to get to anti-SARS-CoV-2 agents in the shortest possible time. The glycoside rutin shows manifold pharmacological activities and, despite its use being limited by its poor solubility in water, it is the active principle of many pharmaceutical preparations. We herein report our in silico and experimental investigations of rutin as a SARS-CoV-2 Mpro inhibitor and of its water solubility improvement obtained by mixing it with l-arginine. Tests of the rutinl-arginine mixture in a cellular model of SARS-CoV-2 infection highlighted that the mixture still suffers from unfavorable pharmacokinetic properties, but nonetheless, the results of this study suggest that rutin might be a good starting point for hit optimization. info:eu-repo/grantAgreement/ES/DGA/B25-20R info:eu-repo/grantAgreement/ES/DGA/E45-20R info:eu-repo/grantAgreement/ES/ISCIII/CPII13-00017 info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BES-2017-080739 info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.927 2021 CHEMISTRY, MULTIDISCIPLINARY 65 / 179 = 0.363 2021 Q2 T2 BIOCHEMISTRY & MOLECULAR BIOLOGY 114 / 297 = 0.384 2021 Q2 T2 0.705 2021 Analytical Chemistry 2021 Q1 Drug Discovery 2021 Q1 Pharmaceutical Science 2021 Q1 Molecular Medicine 2021 Q1 Organic Chemistry 2021 Q1 Medicine (miscellaneous) 2021 Q1 5.9 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ostacolo, Carmine Ortega-Alarcon, David Universidad de Zaragoza (orcid)0000-0003-1885-4365 Jimenez-Alesanco, Ana Universidad de Zaragoza (orcid)0000-0003-4726-7821 Ceballos-Laita, Laura (orcid)0000-0003-1892-5063 Vega, Sonia (orcid)0000-0002-1232-6310 Abian, Olga Universidad de Zaragoza (orcid)0000-0001-5664-1729 Velazquez-Campoy, Adrian Universidad de Zaragoza (orcid)0000-0001-5702-4538 Moretti, Silvia Dabrowska, Agnieszka Botwina, Pawel Synowiec, Aleksandra Kula-Pacurar, Anna Pyrc, Krzysztof Iraci, Nunzio Santi, Claudio 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 26, 19 (2021), 6062 [14 pp.] Molecules (Basel, Online) Molecules 1420-3049 4627242 http://zaguan.unizar.es/record/151168/files/texto_completo.pdf Versión publicada 2713952 http://zaguan.unizar.es/record/151168/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151168 articulos driver 2025-10-17-14:16:35 ARTICLE