000151174 001__ 151174
000151174 005__ 20250227101504.0
000151174 0247_ $$2doi$$a10.3390/jpm11040295
000151174 0248_ $$2sideral$$a125283
000151174 037__ $$aART-2021-125283
000151174 041__ $$aeng
000151174 100__ $$aAnnesi, Ferdinanda
000151174 245__ $$aThermal Liquid Biopsy (TLB) of Blood Plasma as a Potential Tool to Help in the Early Diagnosis of Multiple Sclerosis
000151174 260__ $$c2021
000151174 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151174 5203_ $$aBackground: Multiple sclerosis (MS) is frequently characterized by a variety of clinical signs, often exhibiting little specificity. The diagnosis requires a combination of medical observations and instrumental tests, and any support for its objective assessment is helpful. Objective: Herein, we describe the application of thermal liquid biopsy (TLB) of blood plasma samples, a methodology for predicting the occurrence of MS with a noninvasive, quick blood test. Methods: TLB allows one to define an index (TLB score), which provides information about overall real-time alterations in plasma proteome that may be indicative of MS. Results: This pilot study, based on 85 subjects (45 MS patients and 40 controls), showed good performance indexes (sensitivity and specificity both around 70%). The diagnostic methods better discriminate between early stage and low-burden MS patients, and it is not influenced by gender, age, or assumption of therapeutic drugs. TLB is more accurate for patients having low disability level (\u2264 3.0, measured by the expanded disability status scale, EDSS) and a relapsing-remitting diagnosis. Conclusion: Our results suggest that TLB can be applied to MS, especially in an initial phase of the disease when diagnosis is difficult and yet more important (in such cases, accuracy of prediction is close to 80%), as well as in personalized patient periodic monitoring. The next step will be determining its utility in differentiating between MS and other disorders, in particular in inflammatory diseases.
000151174 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-20R$$9info:eu-repo/grantAgreement/ES/DGA/E45-20R$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI15-00663-Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/FI19-00146$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P
000151174 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151174 590__ $$a3.508$$b2021
000151174 591__ $$aMEDICINE, GENERAL & INTERNAL$$b69 / 172 = 0.401$$c2021$$dQ2$$eT2
000151174 591__ $$aHEALTH CARE SCIENCES & SERVICES$$b42 / 110 = 0.382$$c2021$$dQ2$$eT2
000151174 592__ $$a0.757$$b2021
000151174 593__ $$aMedicine (miscellaneous)$$c2021$$dQ2
000151174 594__ $$a1.8$$b2021
000151174 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151174 700__ $$aHermoso-Durán, Sonia
000151174 700__ $$aRizzuti, Bruno
000151174 700__ $$aBruno, Rosalinda
000151174 700__ $$aPirritano, Domenico
000151174 700__ $$aPetrone, Alfredo
000151174 700__ $$aDel Giudice, Francesco
000151174 700__ $$0(orcid)0000-0003-0853-2880$$aOjeda, Jorge$$uUniversidad de Zaragoza
000151174 700__ $$0(orcid)0000-0002-1232-6310$$aVega, Sonia
000151174 700__ $$aSanchez-Gracia, Oscar
000151174 700__ $$0(orcid)0000-0001-5702-4538$$aVelazquez-Campoy, Adrian$$uUniversidad de Zaragoza
000151174 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, Olga$$uUniversidad de Zaragoza
000151174 700__ $$aGuzzi, Rita
000151174 7102_ $$12007$$2265$$aUniversidad de Zaragoza$$bDpto. Métodos Estadísticos$$cÁrea Estadís. Investig. Opera.
000151174 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000151174 773__ $$g11, 4 (2021), 295 [16 pp.]$$pJ. pers. med.$$tJournal of Personalized Medicine$$x2075-4426
000151174 8564_ $$s2848235$$uhttps://zaguan.unizar.es/record/151174/files/texto_completo.pdf$$yVersión publicada
000151174 8564_ $$s2705837$$uhttps://zaguan.unizar.es/record/151174/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151174 909CO $$ooai:zaguan.unizar.es:151174$$particulos$$pdriver
000151174 951__ $$a2025-02-27-09:26:58
000151174 980__ $$aARTICLE