000151221 001__ 151221
000151221 005__ 20251017144641.0
000151221 0247_ $$2doi$$a10.1017/S003329172400343X
000151221 0248_ $$2sideral$$a143004
000151221 037__ $$aART-2025-143004
000151221 041__ $$aeng
000151221 100__ $$aAndersen, Lars Louis
000151221 245__ $$aOptimal dose and pattern of physical activity to prevent diagnosed depression: prospective cohort study
000151221 260__ $$c2025
000151221 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151221 5203_ $$aBackground:Little is known about the dose and pattern of moderate-to-vigorous physical activity (MVPA) to prevent depression. We aimed to assess the prospective association of dose and pattern of accelerometer-derived MVPA with the risk of diagnosed depression.
Methods: We included 74,715 adults aged 40–69 years from the UK Biobank cohort who were free of severe disease at baseline and participated in accelerometer measurements (mean age 55.2 years [SD 7.8]; 58% women). MVPA at baseline was derived through 1-week wrist-worn accelerometry. Diagnosed depression was defined by hospitalization with ICD-10 codes F32.0-F32.A. Restricted cubic splines and Cox regression determined the prospective association of dose and pattern of MVPA with the risk of incident depression.
Results:Over a median 7.9-year follow-up, there were 3,089 (4.1%) incident cases of depression. Higher doses of MVPA were curvilinearly associated with lower depression risk, with the largest minute-per-minute added benefits occurring between 5 (HR 0.99 [95% CI 0.96–0.99]) and 280 (HR 0.67 [95% CI 0.60–0.74]) minutes per week (reference: 0 MVPA minutes).
Conclusion: Regardless of pattern, higher doses of MVPA were associated with lower depression risk in a curvilinear manner, with the greatest incremental benefit per minute occurring during the first 4–5 h per week. Optimal benefits occurred around 15 h/week.
000151221 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151221 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151221 700__ $$aLópez-Bueno, Rubén
000151221 700__ $$aKandola, Aaron
000151221 700__ $$aNúñez-Cortés, Rodrigo
000151221 700__ $$0(orcid)0000-0002-7865-3429$$aLópez-Bueno, Laura
000151221 700__ $$aCalatayud, Joaquín
000151221 773__ $$g55 (2025), [8 pp.]$$pPsychol. med.$$tPsychological Medicine$$x0033-2917
000151221 8564_ $$s464925$$uhttps://zaguan.unizar.es/record/151221/files/texto_completo.pdf$$yVersión publicada
000151221 8564_ $$s3253785$$uhttps://zaguan.unizar.es/record/151221/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151221 909CO $$ooai:zaguan.unizar.es:151221$$particulos$$pdriver
000151221 951__ $$a2025-10-17-14:31:54
000151221 980__ $$aARTICLE