000151277 001__ 151277
000151277 005__ 20251017144608.0
000151277 0247_ $$2doi$$a10.1016/j.bcp.2025.116807
000151277 0248_ $$2sideral$$a143114
000151277 037__ $$aART-2025-143114
000151277 041__ $$aeng
000151277 100__ $$aPuerta, Adrián
000151277 245__ $$aMultimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies
000151277 260__ $$c2025
000151277 5203_ $$aMitochondria-targeting drugs (mitocans) based on organic cations are emerging as powerful and selective cancer therapeutics. In this study, we have evaluated a novel series of oleanolic acid-derived mitocans, revealing nanomolar-range antiproliferative effects against human solid tumor cells. Continuous live-cell imaging revealed extensive cytoplasmic vacuolation, while mechanistic studies identified paraptosis as the dominant form of cell death. Remarkably, in vivo experiments demonstrated significant tumor growth inhibition in mice, with no detectable toxicity at therapeutic doses. These findings highlight the potential of oleanolic acid-derived mitocans as promising candidates for cancer therapy.
000151277 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-116460RB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/AEI/MICNN/PID2021-123059OB-I00
000151277 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000151277 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151277 700__ $$aGonzález-Bakker, Aday
000151277 700__ $$aRomanos, Eduardo
000151277 700__ $$aDomínguez, Inmaculada Aguilar
000151277 700__ $$aMartínez-Montiel, Mónica
000151277 700__ $$aMerino-Montiel, Penélope
000151277 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel
000151277 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno Floría, M. Concepción
000151277 700__ $$aFernández-Bolaños, José G.
000151277 700__ $$aLópez, Óscar
000151277 700__ $$aPadrón, José M.
000151277 773__ $$g234 (2025), 116807 [16 pp.]$$pBiochem. pharmacol.$$tBiochemical Pharmacology$$x0006-2952
000151277 8564_ $$s10720346$$uhttps://zaguan.unizar.es/record/151277/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-03-03
000151277 8564_ $$s2535180$$uhttps://zaguan.unizar.es/record/151277/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-03-03
000151277 909CO $$ooai:zaguan.unizar.es:151277$$particulos$$pdriver
000151277 951__ $$a2025-10-17-14:16:13
000151277 980__ $$aARTICLE