151277 20260307074516.0 doi 10.1016/j.bcp.2025.116807 sideral 143114 ART-2025-143114 eng Puerta, Adrián Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies 2025 Mitochondria-targeting drugs (mitocans) based on organic cations are emerging as powerful and selective cancer therapeutics. In this study, we have evaluated a novel series of oleanolic acid-derived mitocans, revealing nanomolar-range antiproliferative effects against human solid tumor cells. Continuous live-cell imaging revealed extensive cytoplasmic vacuolation, while mechanistic studies identified paraptosis as the dominant form of cell death. Remarkably, in vivo experiments demonstrated significant tumor growth inhibition in mice, with no detectable toxicity at therapeutic doses. These findings highlight the potential of oleanolic acid-derived mitocans as promising candidates for cancer therapy. info:eu-repo/grantAgreement/ES/AEI/PID2020-116460RB-I00 info:eu-repo/grantAgreement/ES/DGA/E07-23R info:eu-repo/grantAgreement/ES/AEI/MICNN/PID2021-123059OB-I00 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion González-Bakker, Aday Romanos, Eduardo Domínguez, Inmaculada Aguilar Martínez-Montiel, Mónica Merino-Montiel, Penélope (orcid)0000-0002-5244-9569 Pérez Herrera, Raquel (orcid)0000-0003-0553-0695 Gimeno Floría, M. Concepción Fernández-Bolaños, José G. López, Óscar Padrón, José M. 234 (2025), 116807 [16 pp.] Biochem. pharmacol. Biochemical Pharmacology 0006-2952 10720346 http://zaguan.unizar.es/record/151277/files/texto_completo.pdf Versión publicada info:eu-repo/date/embargoEnd/2026-03-03 2535180 http://zaguan.unizar.es/record/151277/files/texto_completo.jpg?subformat=icon icon Versión publicada info:eu-repo/date/embargoEnd/2026-03-03 oai:zaguan.unizar.es:151277 articulos driver 2026-03-06-15:18:35 ARTICLE