000151282 001__ 151282
000151282 005__ 20251017144611.0
000151282 0247_ $$2doi$$a10.1016/j.drup.2021.100753
000151282 0248_ $$2sideral$$a124124
000151282 037__ $$aART-2021-124124
000151282 041__ $$aeng
000151282 100__ $$aStankovic, T.
000151282 245__ $$aIn vitro biomimetic models for glioblastoma-a promising tool for drug response studies
000151282 260__ $$c2021
000151282 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151282 5203_ $$aThe poor response of glioblastoma to current treatment protocols is a consequence of its intrinsic drug resistance. Resistance to chemotherapy is primarily associated with considerable cellular heterogeneity, and plasticity of glioblastoma cells, alterations in gene expression, presence of specific tumor microenvironment conditions and blood-brain barrier. In an attempt to successfully overcome chemoresistance and better understand the biological behavior of glioblastoma, numerous tri-dimensional (3D) biomimetic models were developed in the past decade. These novel advanced models are able to better recapitulate the spatial organization of glioblastoma in a real time, therefore providing more realistic and reliable evidence to the response of glioblastoma to therapy. Moreover, these models enable the fine-tuning of different tumor microenvironment conditions and facilitate studies on the effects of the tumor microenvironment on glioblastoma chemoresistance. This review outlines current knowledge on the essence of glioblastoma chemoresistance and describes the progress achieved by 3D biomimetic models. Moreover, comprehensive literature assessment regarding the influence of 3D culturing and microenvironment mimicking on glioblastoma gene expression and biological behavior is also provided. The contribution of the blood-brain barrier as well as the blood-tumor barrier to glioblastoma chemoresistance is also reviewed from the perspective of 3D biomimetic models. Finally, the role of mathematical models in predicting 3D glioblastoma behavior and drug response is elaborated. In the future, technological innovations along with mathematical simulations should create reliable 3D biomimetic systems for glioblastoma research that should facilitate the identification and possibly application in preclinical drug testing and precision medicine.
000151282 536__ $$9info:eu-repo/grantAgreement/EC/H2020/829010/EU/Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices/PRIME$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 829010-PRIME$$9info:eu-repo/grantAgreement/ES/ISCIII/PFIS/IF16-00050$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-110895RB-I00
000151282 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000151282 590__ $$a22.841$$b2021
000151282 591__ $$aPHARMACOLOGY & PHARMACY$$b2 / 279 = 0.007$$c2021$$dQ1$$eT1
000151282 592__ $$a3.845$$b2021
000151282 593__ $$aCancer Research$$c2021$$dQ1
000151282 593__ $$aPharmacology (medical)$$c2021$$dQ1
000151282 593__ $$aPharmacology$$c2021$$dQ1
000151282 593__ $$aInfectious Diseases$$c2021$$dQ1
000151282 594__ $$a30.8$$b2021
000151282 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151282 700__ $$0(orcid)0000-0001-7232-7588$$aRandelovic, T.
000151282 700__ $$aDragoj, M.
000151282 700__ $$aStojkovic Buric, S.
000151282 700__ $$0(orcid)0000-0001-5376-4440$$aFernández, L.$$uUniversidad de Zaragoza
000151282 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, I.$$uUniversidad de Zaragoza
000151282 700__ $$aPérez-García, V.M.
000151282 700__ $$aPešic, M.
000151282 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000151282 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000151282 773__ $$g55 (2021), 100753 [24 pp.]$$pDrug resist. updat.$$tDRUG RESISTANCE UPDATES$$x1368-7646
000151282 8564_ $$s2188397$$uhttps://zaguan.unizar.es/record/151282/files/texto_completo.pdf$$yVersión publicada
000151282 8564_ $$s2428292$$uhttps://zaguan.unizar.es/record/151282/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151282 909CO $$ooai:zaguan.unizar.es:151282$$particulos$$pdriver
000151282 951__ $$a2025-10-17-14:17:20
000151282 980__ $$aARTICLE