000151294 001__ 151294
000151294 005__ 20251017144613.0
000151294 0247_ $$2doi$$a10.1038/s41366-021-00795-5
000151294 0248_ $$2sideral$$a124234
000151294 037__ $$aART-2021-124234
000151294 041__ $$aeng
000151294 100__ $$aHüls, A.
000151294 245__ $$aPolygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents
000151294 260__ $$c2021
000151294 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151294 5203_ $$aBackground: Childhood obesity is a complex multifaceted condition, which is influenced by genetics, environmental factors, and their interaction. However, these interactions have mainly been studied in twin studies and evidence from population-based cohorts is limited. Here, we analyze the interaction of an obesity-related genome-wide polygenic risk score (PRS) with sociodemographic and lifestyle factors for BMI and waist circumference (WC) in European children and adolescents. Methods: The analyses are based on 8609 repeated observations from 3098 participants aged 2–16 years from the IDEFICS/I.Family cohort. A genome-wide polygenic risk score (PRS) was calculated using summary statistics from independent genome-wide association studies of BMI. Associations were estimated using generalized linear mixed models adjusted for sex, age, region of residence, parental education, dietary intake, relatedness, and population stratification. Results: The PRS was associated with BMI (beta estimate [95% confidence interval (95%—CI)] = 0.33 [0.30, 0.37], r2 = 0.11, p value = 7.9 × 10-81) and WC (beta [95%—CI] = 0.36 [0.32, 0.40], r2 = 0.09, p value = 1.8 × 10-71). We observed significant interactions with demographic and lifestyle factors for BMI as well as WC. Children from Southern Europe showed increased genetic liability to obesity (BMI: beta [95%—CI] = 0.40 [0.34, 0.45]) in comparison to children from central Europe (beta [95%—CI] = 0.29 [0.23, 0.34]), p-interaction = 0.0066). Children of parents with a low level of education showed an increased genetic liability to obesity (BMI: beta [95%—CI] = 0.48 [0.38, 0.59]) in comparison to children of parents with a high level of education (beta [95%—CI] = 0.30 [0.26, 0.34]), p-interaction = 0.0012). Furthermore, the genetic liability to obesity was attenuated by a higher intake of fiber (BMI: beta [95%—CI] interaction = -0.02 [-0.04, -0.01]) and shorter screen times (beta [95%—CI] interaction = 0.02 [0.00, 0.03]). Conclusions: Our results highlight that a healthy childhood environment might partly offset a genetic predisposition to obesity during childhood and adolescence.
000151294 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151294 590__ $$a5.551$$b2021
000151294 591__ $$aNUTRITION & DIETETICS$$b23 / 90 = 0.256$$c2021$$dQ2$$eT1
000151294 591__ $$aENDOCRINOLOGY & METABOLISM$$b39 / 146 = 0.267$$c2021$$dQ2$$eT1
000151294 592__ $$a1.381$$b2021
000151294 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151294 593__ $$aEndocrinology, Diabetes and Metabolism$$c2021$$dQ1
000151294 594__ $$a8.4$$b2021
000151294 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151294 700__ $$aWright, M.N.
000151294 700__ $$aBogl, L.H.
000151294 700__ $$aKaprio, J.
000151294 700__ $$aLissner, L.
000151294 700__ $$aMolnár, D.
000151294 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000151294 700__ $$aDe Henauw, S.
000151294 700__ $$aSiani, A.
000151294 700__ $$aVeidebaum, T.
000151294 700__ $$aAhrens, W.
000151294 700__ $$aPigeot, I.
000151294 700__ $$aForaita, R.
000151294 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000151294 773__ $$g45 (2021), 1321-1330$$pInt. j. obes.$$tINTERNATIONAL JOURNAL OF OBESITY$$x0307-0565
000151294 8564_ $$s997272$$uhttps://zaguan.unizar.es/record/151294/files/texto_completo.pdf$$yVersión publicada
000151294 8564_ $$s2513057$$uhttps://zaguan.unizar.es/record/151294/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151294 909CO $$ooai:zaguan.unizar.es:151294$$particulos$$pdriver
000151294 951__ $$a2025-10-17-14:18:22
000151294 980__ $$aARTICLE