000151308 001__ 151308
000151308 005__ 20250307114715.0
000151308 0247_ $$2doi$$a10.1159/000514378
000151308 0248_ $$2sideral$$a124285
000151308 037__ $$aART-2021-124285
000151308 041__ $$aeng
000151308 100__ $$aDe La Calle, M.
000151308 245__ $$aGestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies
000151308 260__ $$c2021
000151308 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151308 5203_ $$aObjective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE) (PROGNOSIS), Study of Early-onset PE in Spain (STEPS), and a multicenter case-control study. Median, 5th, and 95th percentiles for sFlt-1, PlGF, and the sFlt-1/PlGF ratios were determined for normal twin pregnancies for 7 gestational windows and compared with the previous data for singleton pregnancies. Results: The reference range analysis included 269 women with normal twin pregnancies. Before 29 weeks'' gestation, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios did not differ between twin and singleton pregnancies. From 29 weeks'' gestation to delivery, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios were substantially higher in twin versus singleton pregnancies. sFlt-1 values were higher in women with twin pregnancies across all gestational windows. PlGF values were similar or higher in twin versus singleton pregnancies; PlGF concentrations increased from 10 weeks + 0 days to 28 weeks + 6 days'' gestation. Conclusions: Reference ranges for the sFlt-1/PlGF ratio are similar in women with twin and singleton pregnancies until 29 weeks'' gestation but appear higher in twin pregnancies thereafter.
000151308 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000151308 590__ $$a2.208$$b2021
000151308 591__ $$aOBSTETRICS & GYNECOLOGY$$b66 / 85 = 0.776$$c2021$$dQ4$$eT3
000151308 592__ $$a0.935$$b2021
000151308 593__ $$aEmbryology$$c2021$$dQ1
000151308 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2021$$dQ1
000151308 593__ $$aPediatrics, Perinatology and Child Health$$c2021$$dQ1
000151308 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151308 594__ $$a4.2$$b2021
000151308 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151308 700__ $$aDelgado, J.L.
000151308 700__ $$aVerlohren, S.
000151308 700__ $$aEscudero, A.I.
000151308 700__ $$aBartha, J.L.
000151308 700__ $$0(orcid)0000-0002-0306-8858$$aCampillos, J.M.$$uUniversidad de Zaragoza
000151308 700__ $$aAguarón De La Cruz, A.
000151308 700__ $$aChantraine, F.
000151308 700__ $$aGarcía Hernández, J.Á.
000151308 700__ $$aHerraiz, I.
000151308 700__ $$aLlurba, E.
000151308 700__ $$aKurka, H.
000151308 700__ $$aGuo, G.
000151308 700__ $$aSillman, J.
000151308 700__ $$aHund, M.
000151308 700__ $$aPerales Marín, A.
000151308 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000151308 773__ $$g48, 4 (2021), 288–296$$pFetal diagn. ther.$$tFetal Diagnosis and Therapy$$x1015-3837
000151308 8564_ $$s419970$$uhttps://zaguan.unizar.es/record/151308/files/texto_completo.pdf$$yVersión publicada
000151308 8564_ $$s2388986$$uhttps://zaguan.unizar.es/record/151308/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151308 909CO $$ooai:zaguan.unizar.es:151308$$particulos$$pdriver
000151308 951__ $$a2025-03-07-09:31:50
000151308 980__ $$aARTICLE