151308 20251017144616.0 doi 10.1159/000514378 sideral 124285 ART-2021-124285 eng De La Calle, M. Gestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies 2021 Access copy available to the general public Unrestricted Objective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE) (PROGNOSIS), Study of Early-onset PE in Spain (STEPS), and a multicenter case-control study. Median, 5th, and 95th percentiles for sFlt-1, PlGF, and the sFlt-1/PlGF ratios were determined for normal twin pregnancies for 7 gestational windows and compared with the previous data for singleton pregnancies. Results: The reference range analysis included 269 women with normal twin pregnancies. Before 29 weeks'' gestation, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios did not differ between twin and singleton pregnancies. From 29 weeks'' gestation to delivery, median, 5th, and 95th percentiles for sFlt-1/PlGF ratios were substantially higher in twin versus singleton pregnancies. sFlt-1 values were higher in women with twin pregnancies across all gestational windows. PlGF values were similar or higher in twin versus singleton pregnancies; PlGF concentrations increased from 10 weeks + 0 days to 28 weeks + 6 days'' gestation. Conclusions: Reference ranges for the sFlt-1/PlGF ratio are similar in women with twin and singleton pregnancies until 29 weeks'' gestation but appear higher in twin pregnancies thereafter. info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.208 2021 OBSTETRICS & GYNECOLOGY 66 / 85 = 0.776 2021 Q4 T3 0.935 2021 Embryology 2021 Q1 Radiology, Nuclear Medicine and Imaging 2021 Q1 Pediatrics, Perinatology and Child Health 2021 Q1 Medicine (miscellaneous) 2021 Q1 4.2 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Delgado, J.L. Verlohren, S. Escudero, A.I. Bartha, J.L. Campillos, J.M. Universidad de Zaragoza (orcid)0000-0002-0306-8858 Aguarón De La Cruz, A. Chantraine, F. García Hernández, J.Á. Herraiz, I. Llurba, E. Kurka, H. Guo, G. Sillman, J. Hund, M. Perales Marín, A. 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 48, 4 (2021), 288–296 Fetal diagn. ther. Fetal Diagnosis and Therapy 1015-3837 419970 http://zaguan.unizar.es/record/151308/files/texto_completo.pdf Versión publicada 2388986 http://zaguan.unizar.es/record/151308/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151308 articulos driver 2025-10-17-14:19:14 ARTICLE