000151316 001__ 151316 000151316 005__ 20251017144619.0 000151316 0247_ $$2doi$$a10.3390/biom11050649 000151316 0248_ $$2sideral$$a126625 000151316 037__ $$aART-2021-126625 000151316 041__ $$aeng 000151316 100__ $$aToledano-Díaz A. 000151316 245__ $$aReflections on cerebellar neuropathology in classical scrapie 000151316 260__ $$c2021 000151316 5060_ $$aAccess copy available to the general public$$fUnrestricted 000151316 5203_ $$aIn this review, the most important neuropathological changes found in the cerebella of sheep affected by classical natural scrapie are discussed. This disease is the oldest known of a group of unconventional “infections” caused by toxic prions of different origins. Scrapie is currently considered a “transmissible spongiform encephalopathy” (due to its neuropathological characteristics and its transmission), which is the paradigm of prion pathologies as well as many encephalopathies (prion-like) that present aberrant deposits of insoluble protein with neurotoxic effects due to errors in their catabolization (“misfolding protein diseases”). The study of this disease is, therefore, of great relevance. Our work data from the authors’ previous publications as well as other research in the field. The four most important types of neuropathological changes are neuron abnormalities and loss, neurogliosis, tissue vacuolization (spongiosis) and pathological or abnormal prion protein (PrP) deposits/deposition. These findings were analyzed and compared to other neuropathologies. Various aspects related to the presentation and progression of the disease, the involution of different neuronal types, the neuroglial responses and the appearance of abnormal PrP deposits are discussed. The most important points of controversy in scrapie neuropathology are presented. 000151316 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000151316 590__ $$a6.064$$b2021 000151316 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 297 = 0.253$$c2021$$dQ2$$eT1 000151316 592__ $$a1.019$$b2021 000151316 593__ $$aMolecular Biology$$c2021$$dQ2 000151316 593__ $$aBiochemistry$$c2021$$dQ2 000151316 594__ $$a5.7$$b2021 000151316 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000151316 700__ $$aÁlvarez M.I. 000151316 700__ $$aRodríguez J.-J. 000151316 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola J.J.$$uUniversidad de Zaragoza 000151316 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón M.$$uUniversidad de Zaragoza 000151316 700__ $$aToledano A. 000151316 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000151316 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología 000151316 773__ $$g11, 5 (2021), 649 [24 pp.]$$tBiomolecules$$x2218-273X 000151316 8564_ $$s9115434$$uhttps://zaguan.unizar.es/record/151316/files/texto_completo.pdf$$yVersión publicada 000151316 8564_ $$s2775480$$uhttps://zaguan.unizar.es/record/151316/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000151316 909CO $$ooai:zaguan.unizar.es:151316$$particulos$$pdriver 000151316 951__ $$a2025-10-17-14:20:53 000151316 980__ $$aARTICLE