151316 20251017144619.0 doi 10.3390/biom11050649 sideral 126625 ART-2021-126625 eng Toledano-Díaz A. Reflections on cerebellar neuropathology in classical scrapie 2021 Access copy available to the general public Unrestricted In this review, the most important neuropathological changes found in the cerebella of sheep affected by classical natural scrapie are discussed. This disease is the oldest known of a group of unconventional “infections” caused by toxic prions of different origins. Scrapie is currently considered a “transmissible spongiform encephalopathy” (due to its neuropathological characteristics and its transmission), which is the paradigm of prion pathologies as well as many encephalopathies (prion-like) that present aberrant deposits of insoluble protein with neurotoxic effects due to errors in their catabolization (“misfolding protein diseases”). The study of this disease is, therefore, of great relevance. Our work data from the authors’ previous publications as well as other research in the field. The four most important types of neuropathological changes are neuron abnormalities and loss, neurogliosis, tissue vacuolization (spongiosis) and pathological or abnormal prion protein (PrP) deposits/deposition. These findings were analyzed and compared to other neuropathologies. Various aspects related to the presentation and progression of the disease, the involution of different neuronal types, the neuroglial responses and the appearance of abnormal PrP deposits are discussed. The most important points of controversy in scrapie neuropathology are presented. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.064 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 75 / 297 = 0.253 2021 Q2 T1 1.019 2021 Molecular Biology 2021 Q2 Biochemistry 2021 Q2 5.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Álvarez M.I. Rodríguez J.-J. Badiola J.J. Universidad de Zaragoza (orcid)0000-0002-7173-7216 Monzón M. Universidad de Zaragoza (orcid)0000-0002-2787-9671 Toledano A. 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 11, 5 (2021), 649 [24 pp.] Biomolecules 2218-273X 9115434 http://zaguan.unizar.es/record/151316/files/texto_completo.pdf Versión publicada 2775480 http://zaguan.unizar.es/record/151316/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151316 articulos driver 2025-10-17-14:20:53 ARTICLE