000151346 001__ 151346
000151346 005__ 20251017144625.0
000151346 0247_ $$2doi$$a10.3389/fphar.2021.600139
000151346 0248_ $$2sideral$$a127140
000151346 037__ $$aART-2021-127140
000151346 041__ $$aeng
000151346 100__ $$aSharifi-Rad, J.
000151346 245__ $$aCinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits
000151346 260__ $$c2021
000151346 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151346 5203_ $$aThe genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.
000151346 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151346 590__ $$a5.988$$b2021
000151346 591__ $$aPHARMACOLOGY & PHARMACY$$b50 / 279 = 0.179$$c2021$$dQ1$$eT1
000151346 592__ $$a1.143$$b2021
000151346 593__ $$aPharmacology (medical)$$c2021$$dQ1
000151346 593__ $$aPharmacology$$c2021$$dQ1
000151346 594__ $$a6.6$$b2021
000151346 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000151346 700__ $$aDey, A.
000151346 700__ $$aKoirala, N.
000151346 700__ $$aShaheen, S.
000151346 700__ $$aEl Omari, N.
000151346 700__ $$aSalehi, B.
000151346 700__ $$aGoloshvili, T.
000151346 700__ $$aCirone Silva, N.C.
000151346 700__ $$aBouyahya, A.
000151346 700__ $$aVitalini, S.
000151346 700__ $$aVaroni, E.M.
000151346 700__ $$aMartorell, M.
000151346 700__ $$aAbdolshahi, A.
000151346 700__ $$aDocea, A.O.
000151346 700__ $$aIriti, M.
000151346 700__ $$aCalina, D.
000151346 700__ $$0(orcid)0000-0002-7972-7119$$aLes, F.
000151346 700__ $$aLópez, V.
000151346 700__ $$aCaruntu, C.
000151346 773__ $$g12 (2021), 600139 [27 pp.]$$pFront. pharmacol.$$tFrontiers in Pharmacology$$x1663-9812
000151346 8564_ $$s2173744$$uhttps://zaguan.unizar.es/record/151346/files/texto_completo.pdf$$yVersión publicada
000151346 8564_ $$s2735605$$uhttps://zaguan.unizar.es/record/151346/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151346 909CO $$ooai:zaguan.unizar.es:151346$$particulos$$pdriver
000151346 951__ $$a2025-10-17-14:23:53
000151346 980__ $$aARTICLE