151346 20251017144625.0 doi 10.3389/fphar.2021.600139 sideral 127140 ART-2021-127140 eng Sharifi-Rad, J. Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits 2021 Access copy available to the general public Unrestricted The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.988 2021 PHARMACOLOGY & PHARMACY 50 / 279 = 0.179 2021 Q1 T1 1.143 2021 Pharmacology (medical) 2021 Q1 Pharmacology 2021 Q1 6.6 2021 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Dey, A. Koirala, N. Shaheen, S. El Omari, N. Salehi, B. Goloshvili, T. Cirone Silva, N.C. Bouyahya, A. Vitalini, S. Varoni, E.M. Martorell, M. Abdolshahi, A. Docea, A.O. Iriti, M. Calina, D. Les, F. (orcid)0000-0002-7972-7119 López, V. Caruntu, C. 12 (2021), 600139 [27 pp.] Front. pharmacol. Frontiers in Pharmacology 1663-9812 2173744 http://zaguan.unizar.es/record/151346/files/texto_completo.pdf Versión publicada 2735605 http://zaguan.unizar.es/record/151346/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151346 articulos driver 2025-10-17-14:23:53 ARTICLE