151381 20251017144628.0 doi 10.3390/ani11061682 sideral 127266 ART-2021-127266 eng Martinez-castillero M. Universidad de Zaragoza Detection of genomic regions with pleiotropic effects for growth and carcass quality traits in the rubia gallega cattle breed 2021 Access copy available to the general public Unrestricted The breeding scheme in the Rubia Gallega cattle population is based upon traits measured in farms and slaughterhouses. In recent years, genomic evaluation has been implemented by using a ssGBLUP (single-step Genomic Best Linear Unbiased Prediction). This procedure can reparameterized to perform ssGWAS (single-step Genome Wide Association Studies) by backsolving the SNP (single nucleotide polymorphisms) effects. Therefore, the objective of this study was to identify genomic regions associated with the genetic variability in growth and carcass quality traits. We implemented a ssGBLUP by using a database that included records for Birth Weight (BW -327, 350 records-), Weaning Weight (WW -83, 818-), Cold Carcass Weight (CCW -91, 621-), Fatness (FAT - 91, 475-) and Conformation (CON-91, 609-). The pedigree included 464, 373 individuals, 2, 449 of which were genotyped. After a process of filtering, we ended up using 43, 211 SNP markers. We used the GBLUP and SNPBLUP model equivalences to obtain the effects of the SNPs and then calculated the percentage of variance explained by the regions of the genome between 1 Mb. We identified 7 regions of the genome for CCW; 8 regions for BW, WW, FAT and 9 regions for CON, which explained the percentage of variance above 0.5%. Furthermore, a number of the genome regions had pleiotropic effects, located at: BTA1 (131-132 Mb), BTA2 (1-11 Mb), BTA3 (32-33 Mb), BTA6 (36- 38 Mb), BTA16 (24-26 Mb), and BTA 21 (56-57 Mb). These regions contain, amongst others, the fol-lowing candidate genes: NCK1, MSTN, KCNA3, LCORL, NCAPG, and RIN3. info:eu-repo/grantAgreement/EUR/FEADER/2019-053A info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.231 2021 VETERINARY SCIENCES 16 / 145 = 0.11 2021 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 62 = 0.21 2021 Q1 T1 0.61 2021 Veterinary (miscellaneous) 2021 Q1 Animal Science and Zoology 2021 Q1 2.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Then C. Universidad de Zaragoza (orcid)0000-0002-3042-2250 Altarriba J. Srihi H. López-carbonell D. Universidad de Zaragoza (orcid)0000-0001-6256-5478 Díaz C. Martinez P. Hermida M. Varona L. 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 11, 6 (2021), 1682 [10 pp.] Animals (Basel) Animals 2076-2615 756396 http://zaguan.unizar.es/record/151381/files/texto_completo.pdf Versión publicada 2678495 http://zaguan.unizar.es/record/151381/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151381 articulos driver 2025-10-17-14:25:11 ARTICLE