000151384 001__ 151384
000151384 005__ 20251017144629.0
000151384 0247_ $$2doi$$a10.1007/s00586-025-08686-3
000151384 0248_ $$2sideral$$a143085
000151384 037__ $$aART-2025-143085
000151384 041__ $$aeng
000151384 100__ $$0(orcid)0000-0002-7865-3429$$aLópez-Bueno, Rubén
000151384 245__ $$aAge-threshold for increased risk of developing back disorders: prospective cohort with 74 000 individuals from the UK Biobank
000151384 260__ $$c2025
000151384 5203_ $$aObjective
To investigate the prospective associations between age and the risk of low back disorders (LBD), dorsal disorders (DD), and cervical disorders (CD), and to identify a potential age-threshold for increased risk of back disorders.
Methods
Prospective cohort from the UK Biobank comprising adults with no history of back disorders. We examined different ages and their association with the risk of back disorders derived from diagnoses of hospital registers. Associations were investigated using restricted cubic splines adjusted for sex, racial and ethnic background, tobacco use, Townsend Deprivation Index, alcohol consumption, educational attainment, employment status, self-reported health, diet quality, body mass index, medication use, physical activity, and handgrip strength.
Results
The analytic sample comprised 74,191 participants (mean [SD] age, 55.2 [7.8] years; 57%women) who were followed-up for 7.9 years (IQR = 7.3–8.4). Overall, 3297 (4.3%) cases of incident LBD, 1224 (1.6%) cases of DD, and 792 (1.0%) of CD were documented. The association between age and LBD showed a curvilinear shape with significant higher risk within the range of 61 (hazard ratio [HR] = 1.39 [95%CI,1.02–1.49]) and 70 (HR = 1.71 [95%CI,1.38–2.12]) years (reference:40 years). Similarly, the association of age with DD exhibited a significant curvilinear association within the range of 60 (HR = 1.31 [95%CI,1.01–1.92]) and 70 (HR = 2.74 [95%CI,1.94–3.86]) years. The association between age and CD was not significant.
Conclusions
The risk of LBD and DD, but not CD, increases beyond 60 years of age. Targeting people at this critical age-threshold to prevent risk for LBD and DD may be warranted for future interventions and preventive health programmes.
000151384 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000151384 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151384 700__ $$aAndersen, Lars Louis
000151384 700__ $$aNúñez-Cortés, Rodrigo
000151384 700__ $$aLópez-Bueno, Laura
000151384 700__ $$aSuso-Martí, Luis
000151384 700__ $$aVillafañe, Jorge Hugo
000151384 700__ $$aSalazar-Méndez, Joaquín
000151384 700__ $$aCalatayud, Joaquín
000151384 773__ $$g34 (2025), 861-868$$pEur. spine j.$$tEUROPEAN SPINE JOURNAL$$x0940-6719
000151384 8564_ $$s868671$$uhttps://zaguan.unizar.es/record/151384/files/texto_completo.pdf$$yVersión publicada
000151384 8564_ $$s2044663$$uhttps://zaguan.unizar.es/record/151384/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151384 909CO $$ooai:zaguan.unizar.es:151384$$particulos$$pdriver
000151384 951__ $$a2025-10-17-14:25:47
000151384 980__ $$aARTICLE