000151387 001__ 151387
000151387 005__ 20251017144629.0
000151387 0247_ $$2doi$$a10.1016/j.euroneuro.2025.02.003
000151387 0248_ $$2sideral$$a143089
000151387 037__ $$aART-2025-143089
000151387 041__ $$aeng
000151387 100__ $$aSegura, Alex-González
000151387 245__ $$aMethylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia
000151387 260__ $$c2025
000151387 5203_ $$aBoth genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen's criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0.009), hypertensive disorders during pregnancy (p = 0.004), pre-eclampsia (p = 0.049), early preterm birth (p = 0.030), childhood adversity abuse (p = 0.021) and all childhood adversity (p = 0.030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse.
000151387 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-00325$$9info:eu-repo/grantAgreement/ES/ISCIII/PI14/00612$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00574
000151387 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000151387 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151387 700__ $$aProhens, Llucia
000151387 700__ $$aJulià, Laura
000151387 700__ $$aAmoretti, Silvia
000151387 700__ $$aRIbero, Maria
000151387 700__ $$aPino-Camacho, Laura
000151387 700__ $$aCano-Escalera, Guillermo
000151387 700__ $$aMane, Anna
000151387 700__ $$aRodriguez-Jimenez, Roberto
000151387 700__ $$aRoldan, Alexandra
000151387 700__ $$aSarró, Salvador
000151387 700__ $$aIbañez, Angela
000151387 700__ $$aUsall, Judith
000151387 700__ $$0(orcid)0000-0003-3025-8048$$aLobo, Antonio$$uUniversidad de Zaragoza
000151387 700__ $$aGarcia-Rizo, Clemente
000151387 700__ $$aCuesta, Manuel Jesus
000151387 700__ $$aParellada, Mara
000151387 700__ $$aGonzález-Pinto, Ana
000151387 700__ $$aBerrocoso, Esther
000151387 700__ $$aBernardo, Miquel
000151387 700__ $$aMas, Sergi
000151387 700__ $$aRodríguez, Natalia
000151387 700__ $$aPerez-Ramos, Anaid
000151387 700__ $$aSalmeron, Sergi
000151387 700__ $$aGonzález-Peñas, Javier
000151387 700__ $$aGurriarán, Xaquín
000151387 700__ $$aFarré, Adriana
000151387 700__ $$aPousa, Esther
000151387 700__ $$aZorrilla, Iñaki
000151387 700__ $$aMar-Barrutia, Lorea
000151387 700__ $$aTrabsa, Amira
000151387 700__ $$aMartinez, Laura
000151387 700__ $$aSánchez-Cabezudo, Ángeles
000151387 700__ $$aJiménez-López, Estela
000151387 700__ $$aPomarol-Clotet, Edith
000151387 700__ $$aSalvador, Raymond
000151387 700__ $$aButjosa, Anna
000151387 700__ $$aElena, Rubio-Abadal
000151387 700__ $$aMoreno-Izco, Lucía
000151387 700__ $$aTorres, Ana M. Sánchez
000151387 700__ $$aSaiz, Jeronimo
000151387 700__ $$aLeón-Quismondo, Leticia
000151387 700__ $$aRivero, Olga
000151387 700__ $$aGonzález-Blanco, Leticia
000151387 700__ $$0(orcid)0000-0003-2284-7862$$aCámara Izquierdo, Concepción de la$$uUniversidad de Zaragoza
000151387 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000151387 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000151387 773__ $$g94 (2025), 4-15$$pEur. neuropsychopharmacol.$$tEUROPEAN NEUROPSYCHOPHARMACOLOGY$$x0924-977X
000151387 8564_ $$s4713242$$uhttps://zaguan.unizar.es/record/151387/files/texto_completo.pdf$$yVersión publicada
000151387 8564_ $$s2537454$$uhttps://zaguan.unizar.es/record/151387/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151387 909CO $$ooai:zaguan.unizar.es:151387$$particulos$$pdriver
000151387 951__ $$a2025-10-17-14:25:47
000151387 980__ $$aARTICLE