000151428 001__ 151428
000151428 005__ 20251017144651.0
000151428 0247_ $$2doi$$a10.1002/smll.202412355
000151428 0248_ $$2sideral$$a143131
000151428 037__ $$aART-2025-143131
000151428 041__ $$aeng
000151428 100__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, Javier
000151428 245__ $$aA Highly-Active Chemodynamic Agent Based on In Situ Generated Copper Complexes from Copper Hexacyanoferrate Nanoparticles
000151428 260__ $$c2025
000151428 5203_ $$aCopper hexacyanoferrate (Cu2Fe(CN)6) nanocubes with a homogeneous size under 100 nm are synthesized by self‐assembly from Cu2+ and Fe(CN)63− precursors. Similar to previous reports with catalysts containing Cu and Fe, the objective is to produce a nanoparticle catalyst that can promote glutathione (GSH) oxidation thanks to the Cu contribution, plus some ROS production through Fenton‐like processes fostered by Fe. Unexpectedly, the catalytic activity for GSH oxidation are much higher (≈50%) than those obtained with equal Cu amounts provided as CuCl2. Furthermore, in the presence of GSH concentrations characteristic of the tumor microenvironment, the nanocubes disassembled homogeneously, without a noticeably change of composition. These results suggest that this strong increase of catalytic activity arises from synergistic coordination of the released Cu2+ and Fe(CN)63− ions that facilitate GSH deprotonation, accelerating its oxidation. Given the role of GSH in the nanoparticle disassembly process, a selective action of the catalyst can be obtained: lethal doses as low as 18 ppm of Cu are obtained for U251‐MG cancer cells while healthy fibroblasts are largely spared.
000151428 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R$$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140159NA-I00
000151428 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000151428 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151428 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, José L.$$uUniversidad de Zaragoza
000151428 700__ $$aValls-Chiva, Ángeles$$uUniversidad de Zaragoza
000151428 700__ $$aRuiz-Aranda, Iris
000151428 700__ $$aManzanilla, Brenda
000151428 700__ $$0(orcid)0000-0003-4874-6672$$aGarcía-Peiro, José I.$$uUniversidad de Zaragoza
000151428 700__ $$0(orcid)0000-0002-2866-9369$$aAina, Sergio$$uUniversidad de Zaragoza
000151428 700__ $$0(orcid)0000-0001-9779-5820$$aUrriolabeitia, Esteban
000151428 700__ $$0(orcid)0000-0002-0769-7168$$aAlegre-Requena, Juan V.
000151428 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000151428 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000151428 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000151428 773__ $$g21, 13 (2025), 2412355 [14 pp.]$$pSmall$$tSmall$$x1613-6810
000151428 8564_ $$s4167541$$uhttps://zaguan.unizar.es/record/151428/files/texto_completo.pdf$$yVersión publicada
000151428 8564_ $$s2312207$$uhttps://zaguan.unizar.es/record/151428/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151428 909CO $$ooai:zaguan.unizar.es:151428$$particulos$$pdriver
000151428 951__ $$a2025-10-17-14:36:24
000151428 980__ $$aARTICLE