000151431 001__ 151431
000151431 005__ 20251017144654.0
000151431 0247_ $$2doi$$a10.3390/jcm14041082
000151431 0248_ $$2sideral$$a143026
000151431 037__ $$aART-2025-143026
000151431 041__ $$aeng
000151431 100__ $$aSopeña-Pinilla, Maria
000151431 245__ $$aRetinal Vascular Density and Thickness in Long-Term Type 1 Diabetes Without Visible Vascular Signs of Retinopathy
000151431 260__ $$c2025
000151431 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151431 5203_ $$aBackground: This research seeks to evaluate alterations in blood flow and structural features within the superficial (SCP) and deep (DCP) retinal capillary plexuses, as well as the choriocapillaris (CC), in patients with type 1 diabetes (DM1) who have no diabetic retinopathy (DR) over a period of 4 years. Additionally, the study examines changes in total and inner retinal thickness. Methods: A prospective, longitudinal analysis was conducted using optical coherence tomography (OCT) and OCT angiography (OCTA), involving 25 eyes from 25 DM1 patients with a disease duration of over 15 years. Results: A significant rise in vascular density (VD) was observed in the SCP, with no changes in foveal avascular zone (FAZ) metrics. Minimal changes were noted in the DCP and CC. Morphological abnormalities were frequent, but few changes were noted over time. No major differences were found in overall retinal thickness or inner retinal layers. There was a negative correlation between disease duration and VD in the temporal area of the SCP, as well as between disease duration and GCL++ parafoveal thickness (from the inner limiting membrane (ILM) to the outer limit of the inner plexiform layer (IPL)), along with a reduction in GCL++ perifoveal thickness. Conclusions: In DM1 patients without DR, the SCP VD tends to increase over 4 years, with no notable changes in retinal thickness.
000151431 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000151431 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151431 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151431 700__ $$aArias-Alvarez, Marta$$uUniversidad de Zaragoza
000151431 700__ $$aLopez-Galvez, Maria Isabel
000151431 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000151431 700__ $$0(orcid)0000-0003-1234-9712$$aFernandez-Espinosa, Guisela$$uUniversidad de Zaragoza
000151431 700__ $$aBoned-Murillo, Ana
000151431 700__ $$aDíaz-Barreda, María Dolores
000151431 700__ $$aTomas-Grasa, Cristina
000151431 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000151431 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151431 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000151431 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000151431 773__ $$g14, 4 (2025), 1082 [15 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000151431 8564_ $$s639231$$uhttps://zaguan.unizar.es/record/151431/files/texto_completo.pdf$$yVersión publicada
000151431 8564_ $$s2677262$$uhttps://zaguan.unizar.es/record/151431/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151431 909CO $$ooai:zaguan.unizar.es:151431$$particulos$$pdriver
000151431 951__ $$a2025-10-17-14:37:26
000151431 980__ $$aARTICLE