000151448 001__ 151448
000151448 005__ 20251017144611.0
000151448 0247_ $$2doi$$a10.1186/s13054-024-05096-7
000151448 0248_ $$2sideral$$a143125
000151448 037__ $$aART-2024-143125
000151448 041__ $$aeng
000151448 100__ $$aZwaag, Samanta M.
000151448 245__ $$aThe INTOXICATE study: methodology and preliminary results of a prospective observational study
000151448 260__ $$c2024
000151448 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151448 5203_ $$aBackground
There is currently no practice-based, multicenter database of poisoned patients admitted to intensive care units (ICUs). The INTOXICATE study, endorsed by the ESICM and EAPCCT, aimed to determine the rate of eventful admissions among acutely intoxicated adult ICU patients.
Methods
Ethical approval was obtained for this multicenter, prospective observational study, and data-sharing agreements were signed with each participating center. An electronic case report form was used to collect data on patient demographics, exposure, clinical characteristics, investigations, treatment, and in-hospital mortality data. The primary outcome, ‘eventful admission’, was a composite outcome defined as the rate of patients who received any of the following treatments in the first 24 h after the ICU admission: oxygen supplementation with a FiO2 > 40%, mechanical ventilation, vasopressors, renal replacement therapy (RRT), cardiopulmonary resuscitation, antidotes, active cooling, fluid resuscitation (> 1.5 L of intravenous fluid of any kind), sedation, or who died in the hospital.
Results
Seventy-eight ICUs, mainly from Europe, but also from Australia and the Eastern Mediterranean, participated. A total of 2,273 patients were enrolled between November 2020 and June 2023. The median age of the patients was 41 years, 72% were exposed to intoxicating drugs. The observed rate of patients with an eventful ICU admission was 68% (n = 1546/2273 patients). The hospital mortality was 4.5% (n = 103/2273).
Conclusions
The vast majority of patients survive, and approximately one third of patients do not receive any ICU-specific interventions after admission in an intensive care unit for acute intoxication. High-quality detailed clinical data have been collected from a large cohort of acutely intoxicated ICU patients, providing information on the pattern of severe acute poisoning requiring intensive care admission and the outcomes of these patients.
Trial registration: OSF registration ID: osf.io/7e5uy.
000151448 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000151448 590__ $$a9.3$$b2024
000151448 592__ $$a2.738$$b2024
000151448 591__ $$aCRITICAL CARE MEDICINE$$b4 / 62 = 0.065$$c2024$$dQ1$$eT1
000151448 593__ $$aCritical Care and Intensive Care Medicine$$c2024$$dQ1
000151448 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151448 700__ $$avan den Hengel-Koot, Irma S.
000151448 700__ $$aBaker, Stuart
000151448 700__ $$aDruwé, Patrick
000151448 700__ $$aElhadi, Muhammed
000151448 700__ $$aDufol, Ana Ferrer
000151448 700__ $$aForsberg, Sune
000151448 700__ $$aHalacli, Burcin
000151448 700__ $$aJung, Christian
000151448 700__ $$aLaubner Sakalauskiene, Gabija
000151448 700__ $$aLindqvist, Elin
000151448 700__ $$aMoreno, Rui
000151448 700__ $$aRabe, Christian
000151448 700__ $$aReiter, Nanna
000151448 700__ $$aRezar, Richard
000151448 700__ $$a¿incu, Radu
000151448 700__ $$aTopeli, Arzu
000151448 700__ $$aWood, David M.
000151448 700__ $$ade Lange, Dylan W.
000151448 700__ $$aHunault, Claudine C.
000151448 700__ $$aWamberg, Christian Aage
000151448 700__ $$aAbabneh, Hazim
000151448 700__ $$aAbdulwahed, Eman
000151448 700__ $$aAchterberg, Sefanja
000151448 700__ $$aAlshareea, Entisar Ahmed Ali
000151448 700__ $$aHamed, Aiman Ahmed
000151448 700__ $$aAlali, Mahmoud
000151448 700__ $$aAl-Awwady, Ali Najeh
000151448 700__ $$aAl-Jarrah, Amar
000151448 700__ $$aAl-Juaifari, Maytham A.
000151448 700__ $$aAlnatour, Hazem Zuhair Hussain
000151448 700__ $$aAl-Shami, Khayry
000151448 700__ $$aAltobal, Ahmed
000151448 700__ $$aAl-Touny, Shimaa Ahmed Hamed
000151448 700__ $$aArslan, Mahmut
000151448 700__ $$aAslanidis, Theodoros
000151448 700__ $$aAujayeb, Avinash
000151448 700__ $$aBabayigit, Munire
000151448 700__ $$aBadaras, Robertas
000151448 700__ $$aBarral Segade, Patricia
000151448 700__ $$aBen Hasan, Najat
000151448 700__ $$aBergmans, Dennis C. J. J.
000151448 700__ $$aBilir, Yeliz
000151448 700__ $$aBinnawara, Muhannud
000151448 700__ $$aBiston, Patrick
000151448 700__ $$aBoer, Dirk P.
000151448 700__ $$aBoesen, Hans Christian
000151448 700__ $$aBorggreve, Hella F.
000151448 700__ $$aBrix, Helene
000151448 700__ $$aBrommer, Thirsa
000151448 700__ $$aBueno-Vidales, Nestor
000151448 700__ $$aCanas-Pérez, Isabel
000151448 700__ $$aCarlier, Maxim P.
000151448 700__ $$aCastellanos Esparraguera, Alba
000151448 700__ $$aCekic, Deniz
000151448 700__ $$aChico-Fernández, Mario
000151448 700__ $$aChristiansen, Lisbeth
000151448 700__ $$aCobilinschi, Cristian
000151448 700__ $$aCoelho, Luis
000151448 700__ $$aConstantinescu, Catalin
000151448 700__ $$aCornet, Alexander D.
000151448 700__ $$aCrescioli, Elena
000151448 700__ $$aCuenca-Rubio, Cristina
000151448 700__ $$aDargan, Paul I.
000151448 700__ $$aDarie, Raluca
000151448 700__ $$aDelgado-Moya, Francisco de Paula
000151448 700__ $$aDe Schryver, Nicolas
000151448 700__ $$aDewulf, Bram
000151448 700__ $$aDieperink, Willem
000151448 700__ $$aDubler, Simon
000151448 700__ $$aDuroux, Maree
000151448 700__ $$aElbahnasawy, Mohamed
000151448 700__ $$aEroglu, Ahmet
000151448 700__ $$aEyüpoglu, Selin
000151448 700__ $$aFeria Gil, Raquel
000151448 700__ $$aFernandes, Ana Silva
000151448 700__ $$aFerrer, Carolina
000151448 700__ $$aFranch-Llasat, Diego
000151448 700__ $$aGerritsen, Rik T.
000151448 700__ $$aGhmagh, Reem
000151448 700__ $$aGonzalez Londoño, Juliana
000151448 700__ $$aGrant Sølling, Christoffer
000151448 700__ $$aGravgaard, Kjeld
000151448 700__ $$aGreco, Massimiliano
000151448 700__ $$aGuerreiro, Goncalo
000151448 700__ $$aGustavsson, Nicole
000151448 700__ $$aGüzeldag, Seda
000151448 700__ $$aHamid, Hytham K. S.
000151448 700__ $$aHantson, Philippe
000151448 700__ $$avan Herpt, Thijs T. W.
000151448 700__ $$avan Holten, Jantine
000151448 700__ $$avan der Horst, Femke
000151448 700__ $$aHouwink, Aletta P. I.
000151448 700__ $$aHvass Renner Block, Malene
000151448 700__ $$aKarasiali, Stavri
000151448 700__ $$aKarghul, Mohamed
000151448 700__ $$aKaya, Ebru
000151448 700__ $$aKhamees, Almu'atasim
000151448 700__ $$aKoh, Justin
000151448 700__ $$aKoopmans, Matty
000151448 700__ $$aKovacic, Vedran
000151448 700__ $$avan Lelyveld-Haas, Lenneke E. M.
000151448 700__ $$aLladó Vilar, Meritxell
000151448 700__ $$aLolk, Mette
000151448 700__ $$aMartín-Pérez, Beatriz
000151448 700__ $$aMateo Rodríguez, Eva Maria
000151448 700__ $$aMattijsen, Hélène P.
000151448 700__ $$aMeelad, Ayman
000151448 700__ $$aMiltenburg, Iris
000151448 700__ $$aMohamed Mohamed, Ahmed Ibrahim
000151448 700__ $$aMorgom, Marwa
000151448 700__ $$aMucia-Anayaa, Mercedes
000151448 700__ $$aNafees, Khalid Mahmood Khan
000151448 700__ $$aNassredin, Mohamed
000151448 700__ $$aNurhikmahtul Aqilah, Binti Haji Abd Rashid
000151448 700__ $$avan den Oever, Huub L. A.
000151448 700__ $$aOostdijk, Evelien A. N.
000151448 700__ $$aOzkan Kuscu, Ozlem
000151448 700__ $$aPacheco, Catarina
000151448 700__ $$aPalmqvist, Dorte
000151448 700__ $$aPapachristou, Despoina
000151448 700__ $$aPérez-Torres, David
000151448 700__ $$aPetrisor, Cristina
000151448 700__ $$aPiagnerelli, Michael
000151448 700__ $$aPijper, Wouter
000151448 700__ $$aRoche-Campo, Ferran
000151448 700__ $$aRodriguez-Ruiz, Emilio
000151448 700__ $$aRoetert, Harm
000151448 700__ $$aRuiz-Izquierdo, Jessica
000151448 700__ $$aRuiz Mena, Ana Maria
000151448 700__ $$aRzayeva, Vusala
000151448 700__ $$avan Sabben, Nick
000151448 700__ $$aSaidahmed, Elfayadh
000151448 700__ $$aSandström, Gustaf
000151448 700__ $$aSaracoglu, Kemal Tolga
000151448 700__ $$aSeelmaier, Clemens
000151448 700__ $$aSerck, Nicolas
000151448 700__ $$0(orcid)0000-0002-8068-5016$$aSerón-Arbeloa, Carlos$$uUniversidad de Zaragoza
000151448 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151448 773__ $$g28 (2024), 316 [14 pp.]$$pCrit. care$$tCritical care$$x1364-8535
000151448 8564_ $$s1490860$$uhttps://zaguan.unizar.es/record/151448/files/texto_completo.pdf$$yVersión publicada
000151448 8564_ $$s2196168$$uhttps://zaguan.unizar.es/record/151448/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151448 909CO $$ooai:zaguan.unizar.es:151448$$particulos$$pdriver
000151448 951__ $$a2025-10-17-14:17:19
000151448 980__ $$aARTICLE