151448 20260217205446.0 doi 10.1186/s13054-024-05096-7 sideral 143125 ART-2024-143125 eng Zwaag, Samanta M. The INTOXICATE study: methodology and preliminary results of a prospective observational study 2024 Access copy available to the general public Unrestricted Background There is currently no practice-based, multicenter database of poisoned patients admitted to intensive care units (ICUs). The INTOXICATE study, endorsed by the ESICM and EAPCCT, aimed to determine the rate of eventful admissions among acutely intoxicated adult ICU patients. Methods Ethical approval was obtained for this multicenter, prospective observational study, and data-sharing agreements were signed with each participating center. An electronic case report form was used to collect data on patient demographics, exposure, clinical characteristics, investigations, treatment, and in-hospital mortality data. The primary outcome, ‘eventful admission’, was a composite outcome defined as the rate of patients who received any of the following treatments in the first 24 h after the ICU admission: oxygen supplementation with a FiO2 > 40%, mechanical ventilation, vasopressors, renal replacement therapy (RRT), cardiopulmonary resuscitation, antidotes, active cooling, fluid resuscitation (> 1.5 L of intravenous fluid of any kind), sedation, or who died in the hospital. Results Seventy-eight ICUs, mainly from Europe, but also from Australia and the Eastern Mediterranean, participated. A total of 2,273 patients were enrolled between November 2020 and June 2023. The median age of the patients was 41 years, 72% were exposed to intoxicating drugs. The observed rate of patients with an eventful ICU admission was 68% (n = 1546/2273 patients). The hospital mortality was 4.5% (n = 103/2273). Conclusions The vast majority of patients survive, and approximately one third of patients do not receive any ICU-specific interventions after admission in an intensive care unit for acute intoxication. High-quality detailed clinical data have been collected from a large cohort of acutely intoxicated ICU patients, providing information on the pattern of severe acute poisoning requiring intensive care admission and the outcomes of these patients. Trial registration: OSF registration ID: osf.io/7e5uy. info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 9.3 2024 CRITICAL CARE MEDICINE 4 / 62 = 0.065 2024 Q1 T1 2.738 2024 Critical Care and Intensive Care Medicine 2024 Q1 15.6 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion van den Hengel-Koot, Irma S. Baker, Stuart Druwé, Patrick Elhadi, Muhammed Dufol, Ana Ferrer Forsberg, Sune Halacli, Burcin Jung, Christian Laubner Sakalauskiene, Gabija Lindqvist, Elin Moreno, Rui Rabe, Christian Reiter, Nanna Rezar, Richard ¿incu, Radu Topeli, Arzu Wood, David M. de Lange, Dylan W. Hunault, Claudine C. Wamberg, Christian Aage Ababneh, Hazim Abdulwahed, Eman Achterberg, Sefanja Alshareea, Entisar Ahmed Ali Hamed, Aiman Ahmed Alali, Mahmoud Al-Awwady, Ali Najeh Al-Jarrah, Amar Al-Juaifari, Maytham A. Alnatour, Hazem Zuhair Hussain Al-Shami, Khayry Altobal, Ahmed Al-Touny, Shimaa Ahmed Hamed Arslan, Mahmut Aslanidis, Theodoros Aujayeb, Avinash Babayigit, Munire Badaras, Robertas Barral Segade, Patricia Ben Hasan, Najat Bergmans, Dennis C. J. J. Bilir, Yeliz Binnawara, Muhannud Biston, Patrick Boer, Dirk P. Boesen, Hans Christian Borggreve, Hella F. Brix, Helene Brommer, Thirsa Bueno-Vidales, Nestor Canas-Pérez, Isabel Carlier, Maxim P. Castellanos Esparraguera, Alba Cekic, Deniz Chico-Fernández, Mario Christiansen, Lisbeth Cobilinschi, Cristian Coelho, Luis Constantinescu, Catalin Cornet, Alexander D. Crescioli, Elena Cuenca-Rubio, Cristina Dargan, Paul I. Darie, Raluca Delgado-Moya, Francisco de Paula De Schryver, Nicolas Dewulf, Bram Dieperink, Willem Dubler, Simon Duroux, Maree Elbahnasawy, Mohamed Eroglu, Ahmet Eyüpoglu, Selin Feria Gil, Raquel Fernandes, Ana Silva Ferrer, Carolina Franch-Llasat, Diego Gerritsen, Rik T. Ghmagh, Reem Gonzalez Londoño, Juliana Grant Sølling, Christoffer Gravgaard, Kjeld Greco, Massimiliano Guerreiro, Goncalo Gustavsson, Nicole Güzeldag, Seda Hamid, Hytham K. S. Hantson, Philippe van Herpt, Thijs T. W. van Holten, Jantine van der Horst, Femke Houwink, Aletta P. I. Hvass Renner Block, Malene Karasiali, Stavri Karghul, Mohamed Kaya, Ebru Khamees, Almu'atasim Koh, Justin Koopmans, Matty Kovacic, Vedran van Lelyveld-Haas, Lenneke E. M. Lladó Vilar, Meritxell Lolk, Mette Martín-Pérez, Beatriz Mateo Rodríguez, Eva Maria Mattijsen, Hélène P. Meelad, Ayman Miltenburg, Iris Mohamed Mohamed, Ahmed Ibrahim Morgom, Marwa Mucia-Anayaa, Mercedes Nafees, Khalid Mahmood Khan Nassredin, Mohamed Nurhikmahtul Aqilah, Binti Haji Abd Rashid van den Oever, Huub L. A. Oostdijk, Evelien A. N. Ozkan Kuscu, Ozlem Pacheco, Catarina Palmqvist, Dorte Papachristou, Despoina Pérez-Torres, David Petrisor, Cristina Piagnerelli, Michael Pijper, Wouter Roche-Campo, Ferran Rodriguez-Ruiz, Emilio Roetert, Harm Ruiz-Izquierdo, Jessica Ruiz Mena, Ana Maria Rzayeva, Vusala van Sabben, Nick Saidahmed, Elfayadh Sandström, Gustaf Saracoglu, Kemal Tolga Seelmaier, Clemens Serck, Nicolas Serón-Arbeloa, Carlos Universidad de Zaragoza (orcid)0000-0002-8068-5016 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 28 (2024), 316 [14 pp.] Crit. care Critical care 1364-8535 1490860 http://zaguan.unizar.es/record/151448/files/texto_completo.pdf Versión publicada 2196168 http://zaguan.unizar.es/record/151448/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151448 articulos driver 2026-02-17-20:17:46 ARTICLE