151458 20260418110656.0 doi 10.1002/ejhf.3597 sideral 143172 ART-2025-143172 eng Núñez, Julio Salt repletion and diuretic response: The role of serum chloride. A post-hoc analysis of the <scp>SALT</scp>-<scp>HF</scp> trial on furosemide and hypertonic saline solution administration in ambulatory patients with worsening heart failure 2025 Aims The efficacy of combining hypertonic saline solution (HSS) with loop diuretics in worsening heart failure (WHF) remains uncertain. Hypochloraemia has been associated with reduced diuretic efficacy. Some authors propose that chloride repletion may enhance natriuretic and diuretic responses. This post-hoc analysis of the SALT-HF trial evaluated the effect of single-dose administration of HSS plus intravenous (IV) furosemide versus IV furosemide, stratified by baseline serum chloride. Methods and results The analysis included 148 ambulatory patients with WHF from the double-blind, randomized SALT-HF trial. Participants received either an IV single dose of HSS plus furosemide or IV furosemide. The endpoints were 3-h urinary sodium excretion and diuresis, 7-day congestion score, and 30-day adverse events according to chloride levels. Multivariable linear and logistic regression models assessed the relationship between the intervention and the endpoints. The mean baseline serum chloride level was 100 ± 4 mmol/L. Sixteen patients (10.8%) were identified as hypochloraemic (serum chloride <96 mmol/L), balanced between treatment groups. Patients with hypochloraemia showed a lower natriuretic response (p < 0.05). Interaction analysis revealed a between-treatment differential natriuretic effect based on the chloride levels (pinteraction = 0.008). HSS plus furosemide increased natriuresis compared to furosemide at lower chloride levels. No differential between-treatment effect was found for 3-h diuresis. Similar heterogeneous results were found for the 7-day clinical congestion score and 30-day heart failure events, with a benefit with HSS in patients with lower chloride levels. Conclusion In ambulatory patients with WHF and hypochloraemia, adding HSS to furosemide may improve short-term natriuretic response and outcomes. These findings suggest that chloride supplementation may help overcome diuretic resistance in these patients. info:eu-repo/grantAgreement/ES/ISCIII/PI20-00689 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Miñana, Gema de la Espriella, Rafael Zegrí-Reiriz, Isabel Comín-Colet, Josep Rubio Gracia, Jorge Universidad de Zaragoza (orcid)0000-0002-4769-7154 Morales-Rull, Jose Luis Llàcer, Pau Diez-Villanueva, Pablo de Juan Bagudá, Javier Ortiz Cortés, Carolina Goirigolzarri-Artaza, Josebe García-Pinilla, Jose Manuel Barrios, Elvira del Prado Díaz, Susana Jiménez-Marrero, Santiago Restrepo-Córdoba, Maria Alejandra Testani, Jeffrey Cobo Marcos, Marta 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 27, 6 (2025), 960-971 Eur. j. heart fail. European Journal of Heart Failure 1388-9842 2385500 http://zaguan.unizar.es/record/151458/files/texto_completo.pdf Versión publicada 2019285 http://zaguan.unizar.es/record/151458/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151458 articulos driver 2026-04-18-11:05:07 ARTICLE