151474 20251017144620.0 doi 10.3390/pathogens10050596 sideral 126668 ART-2021-126668 eng Garcés M. (orcid)0000-0001-8385-0219 Novel morphological glial alterations in the spectrum of prion disease types: A focus on common findings 2021 Access copy available to the general public Unrestricted Human prion diseases are a group of rare fatal neurodegenerative diseases with sporadic, genetic, and acquired forms. They are neuropathologically characterized by pathological prion protein accumulation, neuronal death, and vacuolation. Classical immunological response has long been known not to play a major in prion diseases; however, gliosis is known to be a common feature although variable in extent and poorly described. In this investigation, astrogliosis and activated microglia in two brain regions were assessed and compared with non-neurologically affected patients in a representative sample across the spectrum of Creutzfeldt–Jakob disease (CJD) forms and subtypes in order to analyze the influence of prion strain on pathological processes. In this report, we choose to focus on features common to all CJD types rather than the diversity among them. Novel pathological changes in both glial cell types were found to be shared by all CJD types. Microglial activation correlated to astrogliosis. Spongiosis, but not pathological prion protein deposition, correlated to both astrogliosis and microgliosis. At the ultrastructural level, astrocytic glial filaments correlated with pathological changes associated with prion disease. These observations confirm that neuroglia play a prominent role in the neurodegenerative process of prion diseases, regardless of the causative prion type. info:eu-repo/grantAgreement/ES/UZ/2017-BIO-04 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.531 2021 MICROBIOLOGY 58 / 137 = 0.423 2021 Q2 T2 0.901 2021 Immunology and Allergy 2021 Q2 Molecular Biology 2021 Q2 Microbiology (medical) 2021 Q2 Immunology and Microbiology (miscellaneous) 2021 Q2 3.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Guijarro I.M. (orcid)0000-0001-9773-7460 Ritchie D.L. Badiola J.J. Universidad de Zaragoza (orcid)0000-0002-7173-7216 Monzón M. Universidad de Zaragoza (orcid)0000-0002-2787-9671 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 10, 5 (2021), 596 [16 pp.] Pathogens Pathogens 2076-0817 6242520 http://zaguan.unizar.es/record/151474/files/texto_completo.pdf Versión publicada 2800650 http://zaguan.unizar.es/record/151474/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151474 articulos driver 2025-10-17-14:21:34 ARTICLE