000151488 001__ 151488
000151488 005__ 20250310131044.0
000151488 0247_ $$2doi$$a10.1038/s41387-025-00361-2
000151488 0248_ $$2sideral$$a143139
000151488 037__ $$aART-2025-143139
000151488 041__ $$aeng
000151488 100__ $$aRodriguez-Hernandez, Zulema
000151488 245__ $$aDifferential association of selenium exposure with insulin resistance and ß-cell function in middle age and older adults
000151488 260__ $$c2025
000151488 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151488 5203_ $$aObjective
To assess whether the role of selenium on pre-diabetes is differential by age, given comorbidities and decreased β-cell function in older adults.
Research design and methods
We evaluated the cross-sectional association of blood selenium with the homeostatic model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) in middle-aged (Aragon Workers Health Study [AWHS], N = 1186), and older (Seniors ENRICA [Study on Nutrition and Cardiovascular Risk in Spain]-2 [SEN-2], N = 915) diabetes-free adults. A subsample of participants from AWHS (N = 571) and SEN-2 (N = 603) had glucose and insulin repeated measurements for longitudinal analysis. We validated the cross-sectional dose–response associations in the 2011–2018 National Health and Nutrition Examination Survey (NHANES, N = 1317 middle age and N = 960 older) participants. Selenium was measured in whole blood with ICP-MS in AWHS, SEN-2 and NHANES.
Results
The cross-sectional geometric mean ratios (95% confidence intervals) per two-fold selenium increase were 1.09 (1.01, 1.19) for HOMA-IR and 1.15 (1.06, 1.24) for HOMA-β in AWHS; and 1.13 (0.98, 1.31) and 1.03 (0.90, 1.18), in SEN-2. The cross-sectional dose-response associations were consistent in NHANES, with mostly increasingly positive trends for both HOMA endpoints in younger adults and a plateau at levels >~150 μg/L in older adults. The longitudinal dose–response consistently showed positive associations at high selenium dose for both HOMA endpoints in the younger, but not the older, study population.
Conclusions
Increased blood selenium was associated with increased insulin resistance and β-cell function in middle-aged, but not in older individuals, especially for β-cell function. The results suggest that selenium-associated insulin resistance might induce compensatory increased β-cell function at younger ages, being this compensatory capacity decreased with aging.
000151488 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-108973RB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147163OB-C22$$9info:eu-repo/grantAgreement/ES/ISCIII/CPP2022-009718$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071$$9info:eu-repo/grantAgreement/ES/ISCIII/PMPTA22-00107$$9info:eu-repo/grantAgreement/ES/ISCIII/PMPTA23-00012$$9info:eu-repo/grantAgreement/ES/MCIN/PLEC2022-009352$$9info:eu-repo/grantAgreement/ES/MINECO/PI18-01777
000151488 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151488 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151488 700__ $$aBel-Aguilar, Javier
000151488 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belen$$uUniversidad de Zaragoza
000151488 700__ $$aGrau-Perez, Maria
000151488 700__ $$aRedon, Josep
000151488 700__ $$aGomez-Ariza, Jose L.
000151488 700__ $$aGarcia-Barrera, Tamara
000151488 700__ $$aOlmedo, Pablo
000151488 700__ $$aGil, Fernando
000151488 700__ $$aCenarro, Ana
000151488 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000151488 700__ $$0(orcid)0000-0002-1309-4363$$aPuzo, Jose$$uUniversidad de Zaragoza
000151488 700__ $$aCasasnovas, Jose A.$$uUniversidad de Zaragoza
000151488 700__ $$aBanegas, Jose R.
000151488 700__ $$aSotos-Prieto, Mercedes
000151488 700__ $$aOrtola, Rosario
000151488 700__ $$aLaclaustra, Martin
000151488 700__ $$aRodriguez-Artalejo, Fernando
000151488 700__ $$aGarcia-Esquinas, Esther
000151488 700__ $$aTellez-Plaza, Maria
000151488 700__ $$aPastor-Barriuso, Roberto
000151488 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000151488 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151488 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000151488 773__ $$g15, 5 (2025), [8 pp.]$$pNutrition and diabetes$$tNutrition and diabetes$$x2044-4052
000151488 8564_ $$s680617$$uhttps://zaguan.unizar.es/record/151488/files/texto_completo.pdf$$yVersión publicada
000151488 8564_ $$s2893719$$uhttps://zaguan.unizar.es/record/151488/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151488 909CO $$ooai:zaguan.unizar.es:151488$$particulos$$pdriver
000151488 951__ $$a2025-03-10-12:56:50
000151488 980__ $$aARTICLE