000151495 001__ 151495
000151495 005__ 20251017144629.0
000151495 0247_ $$2doi$$a10.1515/almed-2025-0015
000151495 0248_ $$2sideral$$a143146
000151495 037__ $$aART-2025-143146
000151495 041__ $$aeng
000151495 100__ $$aCuenca Alcocel, José
000151495 245__ $$aLipid metabolism in overweight/obese children vs. normal weight children in a north-eastern region of Spain
000151495 260__ $$c2025
000151495 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151495 5203_ $$aObjectives
Obesity and overweight have increased in children and adolescents in Europe in the recent years, accounting for a major global public health problem. The objective of this study was the early detection of metabolic abnormalities in overweight/obese children (8–12 years old) that may ultimately induce impaired glucose metabolism and/or cardiovascular diseases.
Methods
Lipid metabolism and metabolic control parameters were measured and monitored in a group of 61 male and female children with overweight/obesity and a group of 45 healthy, normal weight children, comparing the results obtained. Ages ranged from 8 to 12 years.
Results
Higher levels of triglycerides and insulin and lower levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 were observed in overweight/obese children, as compared to normal weight children. Overweight/obese children exhibited higher apolipoprotein B/apolipoprotein A1 ratio, triglyceride-glucose ratio and HOMA index and a lower low-density lipoprotein (LDL) cholesterol/apolipoprotein B ratio.
Conclusions
Obesity at an early age (8–12 years) negatively affects lipid parameters. Hence, overweight/obese children presented a more atherogenic lipid profile, manifested as higher concentrations of remnant particles and small dense LDL particles, higher insulin resistance and a higher risk for developing diabetes mellitus type 2 and cardiovascular disease, as compared to normal weight children.
000151495 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151495 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151495 700__ $$0(orcid)0000-0002-3847-3300$$aVillalba-Heredia, Lorena
000151495 700__ $$aMartínez Redondo, Inés
000151495 700__ $$aGallego Royo, Alba$$uUniversidad de Zaragoza
000151495 700__ $$0(orcid)0000-0002-7215-6931$$aCasajús, José A.$$uUniversidad de Zaragoza
000151495 700__ $$0(orcid)0000-0002-8982-3737$$aArbonés-Mainar, José M.
000151495 700__ $$aCalmarza, Pilar
000151495 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000151495 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151495 773__ $$g(2025), [9 pp.]$$pAdv. lab. med$$tAdvances in laboratory medicine$$x2628-491X
000151495 8564_ $$s1219502$$uhttps://zaguan.unizar.es/record/151495/files/texto_completo.pdf$$yVersión publicada
000151495 8564_ $$s2781620$$uhttps://zaguan.unizar.es/record/151495/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151495 909CO $$ooai:zaguan.unizar.es:151495$$particulos$$pdriver
000151495 951__ $$a2025-10-17-14:25:34
000151495 980__ $$aARTICLE