000151591 001__ 151591
000151591 005__ 20250319155216.0
000151591 0247_ $$2doi$$a10.1007/s00127-025-02862-y
000151591 0248_ $$2sideral$$a143330
000151591 037__ $$aART-2025-143330
000151591 041__ $$aeng
000151591 100__ $$0(orcid)0000-0002-1252-2397$$aLobo, Elena$$uUniversidad de Zaragoza
000151591 245__ $$aCognitive trajectories in older adults and associated mortality and predictors
000151591 260__ $$c2025
000151591 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151591 5203_ $$aPurpose
To test the hypotheses that declining cognitive aging trajectories would increase mortality risk and that predictors of mortality would differ between trajectory groups.
Methods
This is a sub-study of the ZARADEMP project studying dementia and depression in older adults aged 55 years or more, conducted in Zaragoza, Spain, including 2403 cognitively healthy individuals who had completed at least three of the four waves in a 12-year follow-up. The three cognitive trajectories previously identified were based on the Mini-Mental State Examination (MMSE). Mortality information obtained from the city’s official population registry was registered up to 6 years after the end of the fourth wave of the study. Cox proportional hazard regression analyses for analyzing the risk of death were performed globally and for each cognitive trajectory.
Results
At follow-up, 42.4% of the participants had died. Individuals in class 2-moderate-stable and in class 3-low-and-declining had a 24% and 96%, respectively, higher risk of mortality than those in class 1-high-to-moderate. Those younger and women showed significant lower risks of death in all the classes. Being single, with diabetes, dependency in basic Activities of Daily Living, ex-drinkers, smokers, and ex-smokers increased the risk in class 2. Hypertension showed a higher risk of death in the high-to-moderate group. In the low-and-declining trajectory, anxiety nearly tripled the risk of death.
Conclusion
Trajectories with cognitive decline are associated with higher mortality, with the risk of death showing a gradient. Predictors of mortality differ by cognitive trajectory; the differences being observed even among the cognitively healthier groups.
000151591 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000151591 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151591 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151591 700__ $$0(orcid)0000-0003-2284-7862$$aCámara, Concepción de la$$uUniversidad de Zaragoza
000151591 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, Patricia$$uUniversidad de Zaragoza
000151591 700__ $$0(orcid)0000-0002-6427-6845$$aSaz, Pedro$$uUniversidad de Zaragoza
000151591 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, Raúl$$uUniversidad de Zaragoza
000151591 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000151591 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000151591 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000151591 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000151591 773__ $$g(2025), [9 pp.]$$pSoc. psychiatry psychiatr. epidemiol.$$tSOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY$$x0933-7954
000151591 8564_ $$s928552$$uhttps://zaguan.unizar.es/record/151591/files/texto_completo.pdf$$yVersión publicada
000151591 8564_ $$s1865419$$uhttps://zaguan.unizar.es/record/151591/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151591 909CO $$ooai:zaguan.unizar.es:151591$$particulos$$pdriver
000151591 951__ $$a2025-03-19-14:18:42
000151591 980__ $$aARTICLE