151637 20251017144617.0 doi 10.1016/j.ijpsycho.2021.05.012 sideral 126217 ART-2021-126217 eng Hidalgo V. Universidad de Zaragoza (orcid)0000-0003-3920-1099 Diurnal cortisol secretion and health-related quality of life in healthy older people 2021 Access copy available to the general public Unrestricted Several studies have demonstrated that a dysregulated hypothalamic-pituitary-adrenal (HPA) axis is related to worse health status (e.g., depression, posttraumatic stress, or diabetes, among others). However, less is known about the association between the individual''s perception of their own health status and HPA-axis functioning in healthy older people. The aim of the present study was to examine the relationship between HPA-axis functioning and health-related quality of life (HRQoL) in healthy older people. To do this, 140 healthy older people (69 men and 71 women) from 56 to 76 years old collected eight saliva samples on two consecutive weekdays to measure the diurnal cortisol cycle (i.e. awakening cortisol levels, cortisol awakening response (CAR), overall morning cortisol levels, change in the cortisol levels during the day, and bedtime cortisol levels). In addition, they completed the SF-36 questionnaire to obtain a measure of HRQoL (i.e. reflecting physical and mental functional health status). Results showed that higher awakening and bedtime cortisol levels and the CAR were associated with a better perception of both physical and mental health. In addition, the wake-to-bed cortisol slope was only positively related to physical health. No sex differences were found. These findings suggest that the awakening and bedtime cortisol levels and the CAR are the most relevant indices of diurnal cortisol secretion for understanding the relationship between HPA-axis functioning and HRQoL status in older people. info:eu-repo/grantAgreement/ES/DGA-FEDER/S31-20D info:eu-repo/grantAgreement/ES/MICINN/PSI2016-78763-P info:eu-repo/grantAgreement/ES/MICINN/PSI2017-90806-REDT info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.903 2021 PSYCHOLOGY, BIOLOGICAL 7 / 14 = 0.5 2021 Q2 T2 PSYCHOLOGY, EXPERIMENTAL 36 / 91 = 0.396 2021 Q2 T2 PHYSIOLOGY 42 / 81 = 0.519 2021 Q3 T2 NEUROSCIENCES 201 / 275 = 0.731 2021 Q3 T3 PSYCHOLOGY 42 / 80 = 0.525 2021 Q3 T2 0.902 2021 Neuroscience (miscellaneous) 2021 Q2 Neuropsychology and Physiological Psychology 2021 Q2 5.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pulopulos M.M. Universidad de Zaragoza (orcid)0000-0002-7048-3795 Puig-Perez S. Montoliu T. Salvador A. 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 166 (2021), 127-133 Int. j. psychophysiol. International Journal of Psychophysiology 0167-8760 520853 http://zaguan.unizar.es/record/151637/files/texto_completo.pdf Versión publicada 2554707 http://zaguan.unizar.es/record/151637/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151637 articulos driver 2025-10-17-14:20:22 ARTICLE