000151670 001__ 151670
000151670 005__ 20250319155217.0
000151670 0247_ $$2doi$$a10.3390/jcm10091809
000151670 0248_ $$2sideral$$a126604
000151670 037__ $$aART-2021-126604
000151670 041__ $$aeng
000151670 100__ $$aSáiz-Vázquez O.
000151670 245__ $$aDepression as a risk factor for alzheimer’s disease: A systematic review of longitudinal meta-analyses
000151670 260__ $$c2021
000151670 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151670 5203_ $$aAlzheimer’s disease (AD) is the most frequent cause of dementia, linked to morbidity and mortality among elderly patients. Recently, several clinical studies suggested that depression is a potential risk factor for cognitive decline and AD. A review of meta-analyses was performed, calculating pooled odds ratios to estimate the risk of AD in people with a prior diagnosis (or clinically significant symptoms) of depression. A total of six meta-analyses which represented 28 individual studies were analyzed. A significant association between depression and AD was found (OR = 1.54, 95% CI [1.02–2.31]; p = 0.038). The results showed that heterogeneity across studies was substantial. We found a significant positive effect size for clinical measures of depression, but not for symptomatic rating scales, in the association of depression with risk of AD. The type of rating scale used to assess depression and the cut-off criteria selected also moderated the relationship between depression and AD risk. We found that studies that used clinically significant criteria for diagnosis of depression had more consistent and significant results than studies that used symptomatic scales.
000151670 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/PI16-00896$$9info:eu-repo/grantAgreement/ES/ISCIII/CP20-00040$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000151670 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151670 590__ $$a4.964$$b2021
000151670 591__ $$aMEDICINE, GENERAL & INTERNAL$$b55 / 172 = 0.32$$c2021$$dQ2$$eT1
000151670 592__ $$a1.04$$b2021
000151670 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151670 594__ $$a4.4$$b2021
000151670 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151670 700__ $$aGracia-García P.
000151670 700__ $$aUbillos-Landa S.
000151670 700__ $$aPuente-Martínez A.
000151670 700__ $$aCasado-Yusta S.
000151670 700__ $$aOlaya B.
000151670 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara J.$$uUniversidad de Zaragoza
000151670 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000151670 773__ $$g10, 9 (2021), 1809 [16 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000151670 8564_ $$s862381$$uhttps://zaguan.unizar.es/record/151670/files/texto_completo.pdf$$yVersión publicada
000151670 8564_ $$s2738132$$uhttps://zaguan.unizar.es/record/151670/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000151670 951__ $$a2025-03-19-14:20:28
000151670 980__ $$aARTICLE