000151688 001__ 151688 000151688 005__ 20251017144631.0 000151688 0247_ $$2doi$$a10.3390/ijms22105223 000151688 0248_ $$2sideral$$a126263 000151688 037__ $$aART-2021-126263 000151688 041__ $$aeng 000151688 100__ $$aGonzález-Pastor R. 000151688 245__ $$aCombination chemotherapy with cisplatin and chloroquine: Effect of encapsulation in micelles formed by self-assembling hybrid dendritic–linear–dendritic block copolymers 000151688 260__ $$c2021 000151688 5060_ $$aAccess copy available to the general public$$fUnrestricted 000151688 5203_ $$aClinical outcomes of conventional drug combinations are not ideal due to high toxicity to healthy tissues. Cisplatin (CDDP) is the standard component for many cancer treatments, yet its principal dose-limiting side effect is nephrotoxicity. Thus, CDDP is commonly used in combination with other drugs, such as the autophagy inhibitor chloroquine (CQ), to enhance tumor cell killing efficacy and prevent the development of chemoresistance. In addition, nanocarrier-based drug delivery systems can overcome chemotherapy limitations, decreasing side effects and increasing tumor accumulation. The aim of this study was to evaluate the toxicity of CQ and CDDP against tumor and non-tumor cells when used in a combined treatment. For this purpose, two types of mi-celles based on Pluronic® F127 hybrid dendritic–linear–dendritic block copolymers (HDLDBCs) modified with polyester or poly(esteramide) dendrons derived from 2, 2'-bis(hydroxymethyl)propi-onic acid (HDLDBC-bMPA) or 2, 2'-bis(glycyloxymethyl)propionic acid (HDLDBC-bGMPA) were explored as delivery nanocarriers. Our results indicated that the combined treatment with HDLDBC-bMPA(CQ) or HDLDBC-bGMPA(CQ) and CDDP increased cytotoxicity in tumor cells compared to the single treatment with CDDP. Encapsulations demonstrated less short-term cyto-toxicity individually or when used in combination compared to the free drugs. However, and more importantly, a low degree of cytotoxicity against non-tumor cells was maintained, even when drugs were given simultaneously. 000151688 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E47-20R$$9info:eu-repo/grantAgreement/ES/UZ-DGA/T57-17R-P$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-PI19-01007$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PGC2018-093761-B-C31$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PGC2018-097583-B-I00 000151688 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000151688 590__ $$a6.208$$b2021 000151688 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b69 / 297 = 0.232$$c2021$$dQ1$$eT1 000151688 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b50 / 179 = 0.279$$c2021$$dQ2$$eT1 000151688 592__ $$a1.176$$b2021 000151688 593__ $$aComputer Science Applications$$c2021$$dQ1 000151688 593__ $$aInorganic Chemistry$$c2021$$dQ1 000151688 593__ $$aSpectroscopy$$c2021$$dQ1 000151688 593__ $$aOrganic Chemistry$$c2021$$dQ1 000151688 593__ $$aPhysical and Theoretical Chemistry$$c2021$$dQ1 000151688 593__ $$aMolecular Biology$$c2021$$dQ1 000151688 594__ $$a6.9$$b2021 000151688 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000151688 700__ $$0(orcid)0000-0001-6584-6603$$aLancelot A. 000151688 700__ $$aMorcuende-Ventura V. 000151688 700__ $$0(orcid)0000-0003-0063-9456$$aSan Anselmo M$$uUniversidad de Zaragoza 000151688 700__ $$0(orcid)0000-0001-7091-077X$$aSierra T. 000151688 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano J.L.$$uUniversidad de Zaragoza 000151688 700__ $$aMartin-Duque P. 000151688 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000151688 773__ $$g22, 10 (2021), 5223 [19 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596 000151688 8564_ $$s2747377$$uhttps://zaguan.unizar.es/record/151688/files/texto_completo.pdf$$yVersión publicada 000151688 8564_ $$s2821467$$uhttps://zaguan.unizar.es/record/151688/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000151688 909CO $$ooai:zaguan.unizar.es:151688$$particulos$$pdriver 000151688 951__ $$a2025-10-17-14:26:42 000151688 980__ $$aARTICLE