000151692 001__ 151692 000151692 005__ 20250319155218.0 000151692 0247_ $$2doi$$a10.1016/j.ccr.2025.216542 000151692 0248_ $$2sideral$$a143225 000151692 037__ $$aART-2025-143225 000151692 041__ $$aeng 000151692 100__ $$0(orcid)0000-0003-4874-6672$$aGarcia-Peiro, Jose I.$$uUniversidad de Zaragoza 000151692 245__ $$aCopper-based nanoplatforms and their role in cancer therapy 000151692 260__ $$c2025 000151692 5203_ $$aCopper plays both an essential and potentially hazardous role for living systems. This assertion coupled with emerging evidences highlighting the pivotal role of copper in cancer progression, set the basis for advancing copper-based therapies in oncology. In the presence of copper nanostructures, the rules and mechanisms applying within cells to respond and regulate copper levels differ significantly from those governing copper in its ionic state. These different behaviors can be exploited by Nanotechnology to develop new therapeutic strategies against cancer. In this review, we focus on three of these scenarios: (i) disrupt the copper equilibrium either by artificially overloading copper in cancer cells, or depleting the indispensable endogenous copper required by cancer cells; (ii) leverage the synergy between copper nanostructures and other therapies, such as chemo–, radio– and photothermal therapy; (iii) describe the tools currently existing or under development to map and track copper nanostructures which are utilized in therapy, since they have the potential to unveil new cancer cell vulnerabilities. Finally, we elucidate the future pathways and obstacles facing nano‑copper therapy in each particular section, highlighting the scientific complexities and practical challenges essential for its successful transition into clinical practice. 000151692 536__ $$9info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S 000151692 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000151692 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000151692 700__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, Javier 000151692 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza 000151692 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000151692 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente 000151692 773__ $$g534 (2025), 216542 [19 pp.]$$pCoord. chem. rev.$$tCOORDINATION CHEMISTRY REVIEWS$$x0010-8545 000151692 8564_ $$s13774972$$uhttps://zaguan.unizar.es/record/151692/files/texto_completo.pdf$$yVersión publicada 000151692 8564_ $$s2785928$$uhttps://zaguan.unizar.es/record/151692/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000151692 909CO $$ooai:zaguan.unizar.es:151692$$particulos$$pdriver 000151692 951__ $$a2025-03-19-14:20:55 000151692 980__ $$aARTICLE