151692 20260225150303.0 doi 10.1016/j.ccr.2025.216542 sideral 143225 ART-2025-143225 eng Garcia-Peiro, Jose I. Universidad de Zaragoza (orcid)0000-0003-4874-6672 Copper-based nanoplatforms and their role in cancer therapy 2025 Copper plays both an essential and potentially hazardous role for living systems. This assertion coupled with emerging evidences highlighting the pivotal role of copper in cancer progression, set the basis for advancing copper-based therapies in oncology. In the presence of copper nanostructures, the rules and mechanisms applying within cells to respond and regulate copper levels differ significantly from those governing copper in its ionic state. These different behaviors can be exploited by Nanotechnology to develop new therapeutic strategies against cancer. In this review, we focus on three of these scenarios: (i) disrupt the copper equilibrium either by artificially overloading copper in cancer cells, or depleting the indispensable endogenous copper required by cancer cells; (ii) leverage the synergy between copper nanostructures and other therapies, such as chemo–, radio– and photothermal therapy; (iii) describe the tools currently existing or under development to map and track copper nanostructures which are utilized in therapy, since they have the potential to unveil new cancer cell vulnerabilities. Finally, we elucidate the future pathways and obstacles facing nano‑copper therapy in each particular section, highlighting the scientific complexities and practical challenges essential for its successful transition into clinical practice. info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bonet-Aleta, Javier (orcid)0000-0002-1791-0188 Hueso, Jose L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 534 (2025), 216542 [19 pp.] Coord. chem. rev. COORDINATION CHEMISTRY REVIEWS 0010-8545 13958777 http://zaguan.unizar.es/record/151692/files/texto_completo.pdf Versión publicada 2819840 http://zaguan.unizar.es/record/151692/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151692 articulos driver 2026-02-25-14:59:52 ARTICLE