000151696 001__ 151696
000151696 005__ 20250319155218.0
000151696 0247_ $$2doi$$a10.1111/febs.16093
000151696 0248_ $$2sideral$$a126299
000151696 037__ $$aART-2021-126299
000151696 041__ $$aeng
000151696 100__ $$ade Miguel D.
000151696 245__ $$aInflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison
000151696 260__ $$c2021
000151696 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151696 5203_ $$aCytotoxic lymphocytes (CLs), and more specifically Tc and NK cells, are the main executors of cell death in the immune system, playing a key role during both immunosurveillance and immunotherapy. These cells induce regulated cell death (RCD) by different mechanisms, being granular exocytosis and expression of death ligands the most prominent and best characterized ones. Apoptosis, a traditionally considered low-inflammatory type of cell death, has been accepted for years as the paradigm of RCD induced by CLs. However, several recent studies have demonstrated that NK cells and Tc cells can also induce more inflammatory forms of cell death, namely, necroptosis, pyroptosis, and ferroptosis. Activation of these highly inflammatory types of cell death appears to critically contribute to the activation of a successful antitumour immune response. Additionally, the role of specific cell death pathways in immunogenic cell death is still under intense debate, especially considering the interconnections with other inflammatory forms of cell death. These evidences, together with the advent of new cancer immunotherapies, highlight the necessity to deepen our understanding of the link between the cell death triggered by CLs and inflammation. This knowledge will be instrumental to maximize the antitumour potential of immunotherapies, minimizing deleterious effects associated with these treatments. In this review, we will briefly summarize the main features of apoptosis, necroptosis, pyroptosis and ferroptosis, to subsequently discuss the most recent evidences about the role of these RCD pathways during the elimination of cancer cells mediated by CLs and its modulation to increase the efficacy of cancer immunotherapy.
000151696 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R$$9info:eu-repo/grantAgreement/ES/MCIU-AEI/PID2020-113963RB-I00 Desasignar$$9info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R
000151696 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151696 590__ $$a5.622$$b2021
000151696 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b88 / 297 = 0.296$$c2021$$dQ2$$eT1
000151696 592__ $$a1.611$$b2021
000151696 593__ $$aCell Biology$$c2021$$dQ1
000151696 593__ $$aBiochemistry$$c2021$$dQ1
000151696 594__ $$a9.3$$b2021
000151696 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151696 700__ $$aRamirez-Labrada A.
000151696 700__ $$aUranga I.
000151696 700__ $$aHidalgo S.
000151696 700__ $$0(orcid)0000-0002-1861-5981$$aSantiago L.$$uUniversidad de Zaragoza
000151696 700__ $$aGalvez E.M.
000151696 700__ $$aArias M.
000151696 700__ $$0(orcid)0000-0003-0154-0730$$aPardo J.$$uUniversidad de Zaragoza
000151696 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000151696 773__ $$g289, 15 (2021), 4398-4415$$pFEBS J.$$tFEBS Journal$$x1742-464X
000151696 8564_ $$s1247693$$uhttps://zaguan.unizar.es/record/151696/files/texto_completo.pdf$$yVersión publicada
000151696 8564_ $$s2597297$$uhttps://zaguan.unizar.es/record/151696/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151696 909CO $$ooai:zaguan.unizar.es:151696$$particulos$$pdriver
000151696 951__ $$a2025-03-19-14:21:00
000151696 980__ $$aARTICLE