000151700 001__ 151700
000151700 005__ 20250326140434.0
000151700 0247_ $$2doi$$a10.1093/schbul/sbaf012
000151700 0248_ $$2sideral$$a143203
000151700 037__ $$aART-2025-143203
000151700 041__ $$aeng
000151700 100__ $$aBioque, Miquel
000151700 245__ $$aImpact of relapse in BDNF receptors expression in patients with a first episode of schizophrenia
000151700 260__ $$c2025
000151700 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151700 5203_ $$aBackground and Hypothesis
Relapsing after a first episode of schizophrenia (FES) is a main predictor of clinical and functional prognosis. Brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal development and plasticity, and its signaling may be altered by successive relapses.
Design
We assessed the impact of first relapse in the expression of the 2 isoforms of the BDNF tropomyosin-related kinase B (TrkB) receptor (active full-length TrkB-F and inactive truncated TrkB-T) in peripheral blood mononuclear cells from 53 FES patients in clinical remission followed up for 3 years.
Results
The group of participants that relapsed (n = 24) during the follow-up presented a significant decrease in the expression of the active TrkB-F receptor compared to baseline (M = 100 ± 28.13 vs. M = 83.42 ± 33.84, t = 2.5, P = .02), with no changes in the inactive TrkB-T receptor expression nor in BDNF plasma levels. This decrease also led to a significant decline in the F/T ratio (M = 1.13 ± 0.38 vs. 0.94 ± 0.36, t = 2.17, P = .041). No significant differences were found in the receptors’ expression nor in plasma levels in the group of cases that remained in remission (n = 29). These results were not associated with baseline differences between the groups in terms of the BDNF signaling pathway biomarkers, clinical or treatment variables.
Conclusions
These findings highlight the biological impact that a relapse produces over the systemic BDNF-TrkB signaling pathway, potentially undermining crucial neuronal functions. Identifying the actors involved can help design specific interventions for relapse prevention and improve the functional prognosis of people in the early stages of schizophrenia.
000151700 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI17-01066$$9info:eu-repo/grantAgreement/ES/ISCIII/JR19-00024$$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-00325$$9info:eu-repo/grantAgreement/ES/ISCIII/PI14/00612$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-00481$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00721$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01183$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00625$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI18-01055$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI21-00713
000151700 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000151700 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000151700 700__ $$aLlorca-Bofí, Vicent
000151700 700__ $$aMacDowell, Karina S
000151700 700__ $$aAmoretti, Sílvia
000151700 700__ $$aMezquida, Gisela
000151700 700__ $$aCuesta, Manuel J.
000151700 700__ $$aDíaz-Caneja, Covadonga M.
000151700 700__ $$aIbáñez, Ángela
000151700 700__ $$aSegarra, Rafael
000151700 700__ $$aGonzález-Pinto, Ana
000151700 700__ $$aRoldán, Alexandra
000151700 700__ $$aSáiz, Pilar A.
000151700 700__ $$aMané, Anna
000151700 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000151700 700__ $$aMartínez-Pinteño, Albert
000151700 700__ $$aCano-Escalera, Guillermo
000151700 700__ $$aBerrocoso, Esther
000151700 700__ $$aBernardo, Miquel
000151700 700__ $$a2EPs Group
000151700 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000151700 773__ $$g(2025), [12 pp.]$$pSchizophr. bull.$$tSchizophrenia bulletin$$x0586-7614
000151700 8564_ $$s915998$$uhttps://zaguan.unizar.es/record/151700/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-02-20
000151700 8564_ $$s2175294$$uhttps://zaguan.unizar.es/record/151700/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-02-20
000151700 909CO $$ooai:zaguan.unizar.es:151700$$particulos$$pdriver
000151700 951__ $$a2025-03-26-14:03:56
000151700 980__ $$aARTICLE