000151711 001__ 151711
000151711 005__ 20250422120332.0
000151711 0247_ $$2doi$$a10.1186/s12886-025-03947-7
000151711 0248_ $$2sideral$$a143208
000151711 037__ $$aART-2025-143208
000151711 041__ $$aeng
000151711 100__ $$aMechó-García, María
000151711 245__ $$aChange in monochromatic aberrations with accommodation in a large adult population
000151711 260__ $$c2025
000151711 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151711 5203_ $$aBackground
During accommodation, the eye undergoes significant structural changes, altering wavefront aberrations. So, this study aimed to evaluate changes in Zernike coefficients up to the 6th order with different accommodation demands and ages in a large cohort of young adults, considering the decrease in pupil size with the accommodation.
Methods
Aberrometric measurements for 210 healthy subjects aged 18–40 were performed with the irx3 (Imagine Eyes, Orsay, France), stimulating accommodation with the Badal system of the instrument, from 0 to 5 D. Each wavefront was rescaled to a standardized pupil size for each accommodative vergence. Variations of Zernike coefficients were analyzed for each accommodative demand, and the change of Zernike coefficients with age.
Results
The most notable changes observed during accommodation was the increase in C(2,0). Both C(2,±2) astigmatism showed a reduction in magnitude during accommodation. C(4,0) became less positive, or more negative, as accommodation increased. C(3,-1) remained constant as the accommodation demand increased, while C(3,1) showed an increase. Changes were observed with accommodation and age, where C(2,0) had a negative linear relationship. The C(4,0) changed gradually with age only for accommodative demands below 3 D. C(3,±1) decreased with age.
Conclusions
Wavefront aberration coefficients presented changes during accommodation in people aged 20–40 years. C(2,0) underwent the most pronounced changes and C(4,0) changed more with accommodation than other higher-order aberrations. Zernike coefficients C(2,0), C(4,0) and C(3,±1) decreased with age, and C(2,±2) astigmatisms showed an increase in magnitude with age. These findings were made considering the decrease in pupil size with accommodation, highlighting the importance of accounting for pupil diameter variations when evaluating wavefront aberrations.
000151711 536__ $$9info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON
000151711 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151711 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151711 700__ $$0(orcid)0009-0006-7694-8086$$aArcas-Carbonell, María
000151711 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000151711 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, Ana$$uUniversidad de Zaragoza
000151711 700__ $$aFernández-Sánchez, Vicente
000151711 700__ $$aMacedo-de-Araújo, Rute J.
000151711 700__ $$aFernandes, Paulo
000151711 700__ $$aGonzález-Méijome, José Manuel
000151711 700__ $$aRozema, Jos J.
000151711 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000151711 773__ $$g25 (2025), 104 [13 pp.]$$pBMC OPHTHALMOLOGY$$tBMC OPHTHALMOLOGY$$x1471-2415
000151711 8564_ $$s3906248$$uhttps://zaguan.unizar.es/record/151711/files/texto_completo.pdf$$yVersión publicada
000151711 8564_ $$s2290264$$uhttps://zaguan.unizar.es/record/151711/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151711 909CO $$ooai:zaguan.unizar.es:151711$$particulos$$pdriver
000151711 951__ $$a2025-04-22-12:01:40
000151711 980__ $$aARTICLE