000151719 001__ 151719
000151719 005__ 20251017144641.0
000151719 0247_ $$2doi$$a10.3390/ijms24087468
000151719 0248_ $$2sideral$$a143212
000151719 037__ $$aART-2023-143212
000151719 041__ $$aeng
000151719 100__ $$0(orcid)0000-0002-5822-9823$$aLopez-Yus, Marta
000151719 245__ $$aGene Therapy Based on Mesenchymal Stem Cells Derived from Adipose Tissue for the Treatment of Obesity and Its Metabolic Complications
000151719 260__ $$c2023
000151719 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151719 5203_ $$aObesity is a highly prevalent condition often associated with dysfunctional adipose tissue. Stem cell-based therapies have become a promising tool for therapeutic intervention in the context of regenerative medicine. Among all stem cells, adipose-derived mesenchymal stem cells (ADMSCs) are the most easily obtained, have immunomodulatory properties, show great ex vivo expansion capacity and differentiation to other cell types, and release a wide variety of angiogenic factors and bioactive molecules, such as growth factors and adipokines. However, despite the positive results obtained in some pre-clinical studies, the actual clinical efficacy of ADMSCs still remains controversial. Transplanted ADMSCs present a meager rate of survival and proliferation, possibly because of the damaged microenvironment of the affected tissues. Therefore, there is a need for novel approaches to generate more functional ADMSCs with enhanced therapeutic potential. In this context, genetic manipulation has emerged as a promising strategy. In the current review, we aim to summarize several adipose-focused treatments of obesity, including cell therapy and gene therapy. Particular emphasis will be given to the continuum from obesity to metabolic syndrome, diabetes, and underlying non-alcoholic fatty liver disease (NAFLD). Furthermore, we will provide insights into the potential shared adipocentric mechanisms involved in these pathophysiological processes and their remediation using ADMSCs.
000151719 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01366
000151719 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000151719 590__ $$a4.9$$b2023
000151719 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 313 = 0.211$$c2023$$dQ1$$eT1
000151719 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 231 = 0.294$$c2023$$dQ2$$eT1
000151719 592__ $$a1.179$$b2023
000151719 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000151719 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000151719 593__ $$aComputer Science Applications$$c2023$$dQ1
000151719 593__ $$aInorganic Chemistry$$c2023$$dQ1
000151719 593__ $$aSpectroscopy$$c2023$$dQ1
000151719 593__ $$aOrganic Chemistry$$c2023$$dQ1
000151719 593__ $$aMolecular Biology$$c2023$$dQ2
000151719 593__ $$aCatalysis$$c2023$$dQ2
000151719 594__ $$a8.1$$b2023
000151719 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151719 700__ $$aGarcía-Sobreviela, Maria Pilar
000151719 700__ $$adel Moral-Bergos, Raquel
000151719 700__ $$0(orcid)0000-0002-8982-3737$$aArbones-Mainar, Jose M.
000151719 773__ $$g24, 8 (2023), 7468 [22 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000151719 8564_ $$s757711$$uhttps://zaguan.unizar.es/record/151719/files/texto_completo.pdf$$yVersión publicada
000151719 8564_ $$s2670415$$uhttps://zaguan.unizar.es/record/151719/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151719 909CO $$ooai:zaguan.unizar.es:151719$$particulos$$pdriver
000151719 951__ $$a2025-10-17-14:32:05
000151719 980__ $$aARTICLE