000151728 001__ 151728
000151728 005__ 20250319155218.0
000151728 0247_ $$2doi$$a10.3390/cells13050380
000151728 0248_ $$2sideral$$a143213
000151728 037__ $$aART-2024-143213
000151728 041__ $$aeng
000151728 100__ $$0(orcid)0000-0002-5822-9823$$aLopez-Yus, Marta
000151728 245__ $$aUnraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition
000151728 260__ $$c2024
000151728 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151728 5203_ $$aAdipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses. It comprises mainly two types: white adipose tissue (WAT) for energy storage and brown adipose tissue (BAT) for thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, is involved in various metabolic activities, notably lipogenesis and lipolysis, critical for maintaining energy homeostasis. It also functions as an endocrine organ, secreting adipokines that influence metabolic, inflammatory, and immune processes. However, dysfunction in WAT, especially related to obesity, leads to metabolic disturbances, including the inability to properly store excess lipids, resulting in ectopic fat deposition in organs like the liver, contributing to non-alcoholic fatty liver disease (NAFLD). This narrative review delves into the multifaceted roles of WAT, its composition, metabolic functions, and the pathophysiology of WAT dysfunction. It also explores diagnostic approaches for adipose-related disorders, emphasizing the importance of accurately assessing AT distribution and understanding the complex relationships between fat compartments and metabolic health. Furthermore, it discusses various therapeutic strategies, including innovative therapeutics like adipose-derived mesenchymal stem cells (ADMSCs)-based treatments and gene therapy, highlighting the potential of precision medicine in targeting obesity and its associated complications.
000151728 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01366
000151728 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151728 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151728 700__ $$aHörndler, Carlos
000151728 700__ $$aBorlan, Sofia
000151728 700__ $$aBernal-Monterde, Vanesa$$uUniversidad de Zaragoza
000151728 700__ $$0(orcid)0000-0002-8982-3737$$aArbones-Mainar, Jose M.
000151728 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151728 773__ $$g13, 5 (2024), 380 [20 pp.]$$pCells$$tCells$$x2073-4409
000151728 8564_ $$s909188$$uhttps://zaguan.unizar.es/record/151728/files/texto_completo.pdf$$yVersión publicada
000151728 8564_ $$s2666239$$uhttps://zaguan.unizar.es/record/151728/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151728 909CO $$ooai:zaguan.unizar.es:151728$$particulos$$pdriver
000151728 951__ $$a2025-03-19-14:21:38
000151728 980__ $$aARTICLE