000151730 001__ 151730 000151730 005__ 20250319155218.0 000151730 0247_ $$2doi$$a10.1007/s11538-025-01417-1 000151730 0248_ $$2sideral$$a143206 000151730 037__ $$aART-2025-143206 000151730 041__ $$aeng 000151730 100__ $$aSabir, Soukaina 000151730 245__ $$aMathematical Model of CAR T-Cell Therapy for a B-Cell Lymphoma Lymph Node 000151730 260__ $$c2025 000151730 5060_ $$aAccess copy available to the general public$$fUnrestricted 000151730 5203_ $$aCAR T-cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults. However, their effectiveness in treating B-cell lymphomas has been limited in comparison to leukemia. In this paper we present a mathematical model that elucidates the dynamics of diffuse large B-cell lymphoma and CAR T-cells in a lymph node. The mathematical model aids in understanding the complex interplay between the cell populations involved and proposes ways to identify potential underlying dynamical causes of treatment failure. We also study the phenomenon of immunosuppression induced by tumor cells and theoretically demonstrate its impact on cell dynamics. Through the examination of various response scenarios, we underscore the significance of product characteristics in treatment outcomes. 000151730 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E24-23R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2022-142341OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 000151730 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000151730 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000151730 700__ $$aLeón-Triana, Odelaisy 000151730 700__ $$0(orcid)0000-0002-5701-1670$$aSerrano, Sergio$$uUniversidad de Zaragoza 000151730 700__ $$0(orcid)0000-0002-8089-343X$$aBarrio, Roberto$$uUniversidad de Zaragoza 000151730 700__ $$aPérez-García, Victor M. 000151730 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada 000151730 773__ $$g87, 3 (2025), 33$$pBull. math. biol.$$tBULLETIN OF MATHEMATICAL BIOLOGY$$x0092-8240 000151730 8564_ $$s4025736$$uhttps://zaguan.unizar.es/record/151730/files/texto_completo.pdf$$yVersión publicada 000151730 8564_ $$s1318203$$uhttps://zaguan.unizar.es/record/151730/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000151730 909CO $$ooai:zaguan.unizar.es:151730$$particulos$$pdriver 000151730 951__ $$a2025-03-19-14:21:40 000151730 980__ $$aARTICLE