Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions

Micheloud J.F. ; Luján L. (Universidad de Zaragoza) ; Colque-Caro L.A. ; Núñez-Montoya S.C. ; Barbeito C.G. ; Portiansky E.L. ; Gimeno E.J.

Resumen: Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 µg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.

Idioma: Inglés

DOI: 10.1177/0300985821999322

Año: 2021

Publicado en: Veterinary Pathology 58, 3 (2021), 568-573
ISSN: 0300-9858

Factor impacto JCR: 3.157 (2021)

Categ. JCR: VETERINARY SCIENCES rank: 18 / 145 = 0.124 (2021) - Q1 - T1
Categ. JCR: PATHOLOGY rank: 40 / 77 = 0.519 (2021) - Q3 - T2

Factor impacto CITESCORE: 4.3 - Veterinary (Q1)

Factor impacto SCIMAGO: 0.768 - Veterinary (miscellaneous) (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)