152067 20251017144621.0 doi 10.3390/jcm10143045 sideral 126867 ART-2021-126867 eng Cañamares-Orbís, P. New trends and advances in non-variceal gastrointestinal bleeding—series II 2021 Access copy available to the general public Unrestricted The gastrointestinal tract is a long tubular structure wherein any point in the mucosa along its entire length could be the source of a hemorrhage. Upper (esophagel and gastroduodenal) and lower (jejunum, ileum, and colon) gastrointestinal bleeding are common. Gastroduodenal and colonic bleeding are more frequent than bleeding from the small bowel, but nowadays the entire gastrointestinal tract can be explored endoscopically and bleeding lesions can be locally treated successfully to stop or prevent further bleeding. The extensive use of antiplatelet and anticoagulants drugs in cardiovascular patients is, at least in part, the cause of the increasing number of patients suffering from gastrointestinal bleeding. Patients with these conditions are usually older and more fragile because of their comorbidities. The correct management of antithrombotic drugs in cases of gastrointestinal bleeding is essential for a successful outcome for patients. The influence of the microbiome in the pathogenesis of small bowel bleeding is an example of the new data that are emerging as potential therapeutic target for bleeding prevention. This text summarizes the latest research and advances in all forms of acute gastrointestinal bleeding (i.e., upper, small bowel and lower). Diagnosis is approached, and medical, endoscopic or antithrombotic management are discussed in the text in an accessible and comprehensible way. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.964 2021 MEDICINE, GENERAL & INTERNAL 55 / 172 = 0.32 2021 Q2 T1 1.04 2021 Medicine (miscellaneous) 2021 Q1 4.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lanas Arbeloa, Á. Universidad de Zaragoza (orcid)0000-0001-5932-2889 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 10, 14 (2021), 3045 [19 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 369344 http://zaguan.unizar.es/record/152067/files/texto_completo.pdf Versión publicada 2650879 http://zaguan.unizar.es/record/152067/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:152067 articulos driver 2025-10-17-14:21:48 ARTICLE