000152083 001__ 152083
000152083 005__ 20250326144155.0
000152083 0247_ $$2doi$$a10.3390/life11040353
000152083 0248_ $$2sideral$$a126912
000152083 037__ $$aART-2021-126912
000152083 041__ $$aeng
000152083 100__ $$aPlatero J.L.
000152083 245__ $$aThe impact of epigallocatechin gallate and coconut oil treatment on cortisol activity and depression in multiple sclerosis patients
000152083 260__ $$c2021
000152083 5060_ $$aAccess copy available to the general public$$fUnrestricted
000152083 5203_ $$a(1) Background: Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically by progressive muscle loss and increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) and ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source is coconut oil, have shown emotional benefits and body fat loss. The aim of this study was to assess the impact of EGCG and coconut oil on cortisol activity related to fat loss and depression in MS patients. (2) Methods: The study involved 51 MS patients who were randomly divided into an intervention group or a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, which were included in their daily diet for four months. The control group received placebo and all patients followed an isocaloric diet. A blood sample was collected before and after the four-month period, and levels of cortisol, albumin and BHB were measured in serum. In addition, immediately before and after the intervention, anthropometric variables were measured: waist-to-hip ratio (WHR), body fat mass percentage, fat weight, total weight, and muscle mass percentage. Depression was assessed with the Beck Depression Inventory II (BDI-II). (3) Results: No significant changes were obtained in cortisol levels in any of the groups, and there was a significant increase in albumin in the blood of the intervention group only that could lead to a decrease in serum free cortisol. In addition, it was observed a significant decrease in levels of depression and abdominal fat. (4) Conclusions: EGCG combined with coconut oil increase the concentration of albumin in blood and produce less depression in MS patients.
000152083 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000152083 590__ $$a3.253$$b2021
000152083 591__ $$aBIOLOGY$$b39 / 94 = 0.415$$c2021$$dQ2$$eT2
000152083 592__ $$a0.588$$b2021
000152083 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2021$$dQ2
000152083 593__ $$aSpace and Planetary Science$$c2021$$dQ2
000152083 593__ $$aEcology, Evolution, Behavior and Systematics$$c2021$$dQ2
000152083 594__ $$a1.9$$b2021
000152083 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000152083 700__ $$aCuerda-Ballester M.
000152083 700__ $$aSancho-Cantus D.
000152083 700__ $$aBenlloch M.
000152083 700__ $$aCeron J.J.
000152083 700__ $$aRubio C.P.
000152083 700__ $$aGarcía-Pardo M.P.$$uUniversidad de Zaragoza
000152083 700__ $$aLópez-Rodríguez M.M.
000152083 700__ $$ade la Rubia Ortí J.E.
000152083 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000152083 773__ $$g11, 4 (2021), 353 [12 pp.]$$pLife (Basel)$$tLife$$x2075-1729
000152083 8564_ $$s707427$$uhttps://zaguan.unizar.es/record/152083/files/texto_completo.pdf$$yVersión publicada
000152083 8564_ $$s2718539$$uhttps://zaguan.unizar.es/record/152083/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000152083 909CO $$ooai:zaguan.unizar.es:152083$$particulos$$pdriver
000152083 951__ $$a2025-03-26-13:54:45
000152083 980__ $$aARTICLE