Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFß and activin A suppression

Rea, Anna Santana-Hernández, Sara Villanueva, Javier Sanvicente-García, Marta Cabo, Mariona Suárez-Olmos, Jesús Quimis, Fabricio Qin, Mengjuan Llorens, Eduard Blasco-Benito, Sandra Torralba-Raga, Lamberto Pérez, Lorena Bhattarai, Bishan Alari-Pahissa, Elisenda Georgoudaki, Anna-Maria Balaguer, Francesc Juan, Manel Pardo, Julián Celià-Terrassa, Toni Rovira, Ana Möker, Nina Zhang, Congcong Colonna, Marco Spanholtz, Jan Malmberg, Karl-Johan Montagut, Clara Albanell, Joan Güell, Marc López-Botet Muntasell, Aura Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFß and activin A suppression

Nat. immunol.

10.1038/s41590-025-02103-z 2025

2025