152239 20251017144652.0 doi 10.1177/15346501251324920 sideral 143385 ART-2025-143385 eng San Martín, María Consuelo Evaluating emotional regulation and comorbidities in multiple sclerosis: Insights from a unified protocol treatment case study 2025 Access copy available to the general public Unrestricted This case study presents the application of the Unified Protocol (UP) in a patient dealing with emotional regulation problems in the context of physical health challenges like overweight or obesity, who also was diagnosed with Relapsing-Remitting Multiple Sclerosis (RRMS). The patient, identified as MK, participated in sessions that employed cognitive-behavioral techniques aimed at improving emotional regulation. This intervention was chosen due to its potential to influence MK’s anxiety and depression symptoms, which were presumed to be exacerbated by emotional dysregulation. The treatment proved effective in enhancing MK’s emotional regulation of her anxiety and depressive symptoms. The UP sessions were tailored to address emotional challenges and the physical complexities associated with RRMS. This case study is part of an ongoing Randomized Controlled Trial (RCT) testing the efficacy of the UP in patients with RRMS and obesity using a group intervention approach. The pre-registration for this Randomized Controlled Trial (RCT) can be found at the following link: https://osf.io/sr4bx/?view_only=bcbcff9e43ac4f00b557313442739dca This study highlights the versatility of the UP in managing patients with multiple transdiagnostic symptoms, particularly those involving complex interactions between physical and emotional health issues. Findings suggest that integrating the UP can significantly benefit patients with neurological conditions, offering an integral approach that considers both mental and physical health components. This case study provides valuable insights into the adaptability of cognitive-behavioral interventions in complex clinical scenarios, suggesting further exploration into their broader application in similar contexts. info:eu-repo/grantAgreement/ES/DGA/S31-23R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Beltrán, Rodrigo Pardo-Garrido, Luis Soto, Marcela Matus, Paulina Quezada-Scholz, Vanetza E. Pino, Paulina Osma, Jorge Universidad de Zaragoza (orcid)0000-0002-7293-318X Guevara, Carlos 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. (2025), [25 pp.] Clin. case stud. Clinical case studies 1534-6501 747907 http://zaguan.unizar.es/record/152239/files/texto_completo.pdf Postprint 1655203 http://zaguan.unizar.es/record/152239/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:152239 articulos driver 2025-10-17-14:36:49 ARTICLE